貨號	規格	價格	上海	北京	武漢	南京
S82989-5mg	99.1%	￥570.00 S82989-5mg ￥570.00 現貨	10 10	-	-	-
S82989-10mg	99.1%	￥940.00 S82989-10mg ￥940.00 現貨	10 10	-	-	-
S82989-50mg	99.1%	￥2700.00 S82989-50mg ￥2700.00 現貨	7 7	-	-	-

產品介紹

DG172 dihydrochloride is a selective PPARβ/δ antagonist, with an IC50 of 27 nM

產品描述：

DG172 dihydrochloride is a selective PPARβ/δ antagonist, with an IC50 of 27 nM

靶點：

PPARβ/δ:27 nM (IC50);PPAR

體外研究：

DG172 dihydrochloride is a selective PPARβ/δ antagonist, with an IC50 of 27 nM. DG172 enhances transcriptional corepressor recruitment, and down-regulates transcription of the PPARβ/δ target gene Angptl4 in mouse myoblasts (IC50, 9.5 nM). DG172 (1 μM) promotes the differentiation of dendritic cells (DCs) from GM-CSF-induced mouse bone marrow cells (BMCs) and reduces Ly6b+/Gr1+ granulocytic cells. DG172 has effects on the transcriptome of GM-CSF differentiated BMCs from WT and Ppard null mice, and acts at a specific stage of GM-CSF-induced differentiation. DG172 (0.1, 1.0 μM) dose-dependently promotes proliferation of TM4 cells. DG172 reduces expression of claudin-11 in TM4 cells

參考文獻：

1. Lieber S, et al. (Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile (DG172): an orally bioavailable PPARβ/δ-selective ligand with inverse agonistic properties. J Med Chem. 2012 Mar 22;55(6):2858-68. 2. Lieber S, et al. The inverse agonist DG172 triggers a PPARβ/δ-independent myeloid lineage shift and promotes GM-CSF/IL-4-induced dendritic cell differentiation. Mol Pharmacol. 2015 Feb;87(2):162-73. 3. Yao PL, et al. Peroxisome Proliferator-activated Receptor-D (PPARD) Coordinates Mouse Spermatogenesis by Modulating Extracellular Signal-regulated Kinase (ERK)-dependent Signaling. J Biol Chem. 2015 Sep 18;290(38):23416-31.

溶解性：

Soluble in H2O

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.197 ml	10.984 ml	21.967 ml
5 mM	0.439 ml	2.197 ml	4.393 ml
10 mM	0.22 ml	1.098 ml	2.197 ml
50 mM	0.044 ml	0.22 ml	0.439 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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DG172 (dihydrochloride)