貨號	規格	價格	上海	北京	武漢	南京
S82962-1mg	99.8%	￥125.00 S82962-1mg ￥125.00 現貨	5 5	-	-	-
S82962-5mg	99.8%	￥230.00 S82962-5mg ￥230.00 現貨	7 7	-	-	-
S82962-10mg	99.8%	￥420.00 S82962-10mg ￥420.00 現貨	6 6	-	-	-
S82962-50mg	99.8%	￥1650.00 S82962-50mg ￥1650.00 現貨	3 3	-	-	-
S82962-100mg	≥99%	￥3200.00 S82962-100mg ￥3200.00 2-3天	0 貨期：2-3天	-	-	-

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產品介紹

Leniolisib (CDZ173) is a potent and selective PI3Kδ inhibitor. Leniolisib has the potential for immunodeficiency disorders treatment.

產品描述：

Leniolisib (CDZ173) is a potent and selective PI3Kδ inhibitor. Leniolisib has the potential for immunodeficiency disorders treatment.

靶點：

PI3Kδ:11 nM (IC50);PI3Kα:280 nM (IC50);PI3Kβ:480 nM (IC50);PI3Kγ:2.57 μM (IC50);DNA-PK:880 nM (IC50);DNA-PK;?PI3K

體外研究：

Expression of APDS mutant p110δ in cell lines and patient-derived lymphocytes lead to increased pathway activity, measured as phosphorylation of AKT or S6, which is suppressed by leniolisib in a concentration dependent way

體內研究：

Oral leniolisib lead to a dose-dependent reduction in PI3K/AKT pathway activity and resolve the immune dysregulation with normalization of circulating transitional and na?ve B cells and reduction in PD-1+CD4+ and senescent CD57+CD8+ T cells. After 12 weeks of treatment, all patients show amelioration of lymphoproliferation with lymph node sizes and spleen volumes reduced by 39% (mean, range 26-57%) and 40% (mean, range: 13-65%), respectively

參考文獻：

1. Rao V, et al. Effective 'Activated PI3Kd Syndrome' -targeted therapy with PI3Kd inhibitor leniolisib. The New England journal of medicine: NEJM. ISSN 0028-4793; 1533-4406

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.22 ml	11.1 ml	22.2 ml
5 mM	0.444 ml	2.22 ml	4.44 ml
10 mM	0.222 ml	1.11 ml	2.22 ml
50 mM	0.044 ml	0.222 ml	0.444 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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