貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S82902-1mg	≥98%	￥1100.00 S82902-1mg ￥1100.00 2-3天	0 貨期：2-3天	-	-	-
S82902-5mg	≥98%	￥3300.00 S82902-5mg ￥3300.00 2-3天	0 貨期：2-3天	-	-	-
S82902-10mg	≥98%	￥5000.00 S82902-10mg ￥5000.00 2-3天	0 貨期：2-3天	-	-	-

大包裝詢價(jià) 收藏產(chǎn)品

加入購物車

到貨通知，提交手機(jī)號(hào)入庫后將短信通知。

產(chǎn)品介紹

MKC9989 is a Hydroxy aryl aldehydes (HAA) inhibitor and also inhibits IRE1α with an IC50 of 0.23 to 44 μM

產(chǎn)品描述：

MKC9989 is a Hydroxy aryl aldehydes (HAA) inhibitor and also inhibits IRE1α with an IC50 of 0.23 to 44 μM

靶點(diǎn)：

IC50: 0.23 to 44 μM (IRE1α);IRE1

體外研究：

At 10 μM concentration, MKC9989 completely inhibits both basal and thapsigargin induced splicing of XBP1 mRNA. These effects are observed even in cells pre-treated with thapsigargin, indicating that MKC9989 can fully reverse the onset of XPB1 splicing after the UPR is initiated. In parallel analysis, MKC9989, significantly stabilizes the RIDD target CD59 mRNA when co-administered with thapsigargin relative to thapsigargin treatment alone and modestly increases levels of CD59 mRNA in non-stressed cells, the latter likely reflects the inhibition of baseline RIDD activity. In contrast to effects on XBP1 splicing, MKC9989 moderately stabilizes CD59 levels when administered 2 hour post treatment with thapsigargin. Finally, the potency of MKC9989 against the splicing of XBP1 mRNA (EC50=0.33 μM) is comparable to its potency against RNA cleavage in vitro

參考文獻(xiàn)：

1. Sanches M, et al. Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors. Nat Commun. 2014 Aug 28;5:4202.

溶解性：

soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.973 ml	14.866 ml	29.732 ml
5 mM	0.595 ml	2.973 ml	5.946 ml
10 mM	0.297 ml	1.487 ml	2.973 ml
50 mM	0.059 ml	0.297 ml	0.595 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

質(zhì)檢證書(COA)

輸入產(chǎn)品批號(hào)：

如何獲取質(zhì)檢證書(COA)?

請(qǐng)輸入貨號(hào)和一個(gè)與之匹配的批號(hào)。
例如:
批號(hào)：JS298415 貨號(hào)：S20001-25g
在貨品標(biāo)簽上如何找到貨號(hào)和批號(hào)?

摩爾濃度計(jì)算器

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

質(zhì)量

濃度

體積

分子摩爾量

計(jì)算重置

玖玖资源网站,爆乳久久久,日韩精品乱码久久久蜜桃,精品呦国产一区二区三区,国产伦高清一区二区三区,sese一区二区,午夜精品福利一区二区三区,三级黄色网站久久免费