貨號	規格	價格	上海	北京	武漢	南京
S82900-5mg	≥98%	￥1553.00 S82900-5mg ￥1553.00 現貨	10 10	-	-	-
S82900-10mg	≥98%	￥2594.00 S82900-10mg ￥2594.00 現貨	10 10	-	-	-
S82900-25mg	≥98%	￥6179.00 S82900-25mg ￥6179.00 現貨	8 8	-	-	-
S82900-50mg	≥98%	￥9990.00 S82900-50mg ￥9990.00 現貨	4 4	-	-	-

產品介紹

AU1235, an adamantyl urea, is a potent MmpL3 inhibitor. The Mycobacterium tuberculosis protein MmpL3 performs an essential role in cell wall synthesis, since it effects the transport of trehalose monomycolates across the inner membrane

產品描述：

靶點：

Bacterial;Antibacterial

體外研究：

AU1235 is similarly active against MDR isolates of M. tb displaying resistance to isoniazid, rifampicin, and pyrazinamide in addition to streptomycin, fluoroquinolones and/or ethambutol. AU1235 also inhibits Mycobacterium smegmatis and Mycobacterium fortuitum although the MICs (3.2 to 6.4 μg/ml) are significantly higher than against M. tb and M. bovis BCG

參考文獻：

1. McNeil MB, et al. Multiple Mutations in Mycobacterium tuberculosis MmpL3 Increase Resistance to MmpL3 Inhibitors. mSphere. 2020;5(5):e00985-20. Published 2020 Oct 14. 2. Grzegorzewicz AE, et al. Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane. Nat Chem Biol. 2012;8(4):334-341. Published 2012 Feb 19.

溶解性：

soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.083 ml	15.416 ml	30.832 ml
5 mM	0.617 ml	3.083 ml	6.166 ml
10 mM	0.308 ml	1.542 ml	3.083 ml
50 mM	0.062 ml	0.308 ml	0.617 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

質檢證書(COA)

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摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

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濃度

體積

分子摩爾量

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