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產品描述： Avexitide (Exendin (9-39)) is a specific and competitive GLP-1 receptor antagonist. |
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靶點：
GCGR;GlucagonReceptor |
體內研究：
Continuous subcutaneous infusion of Avexitide (Exendin (9-39)) significantly raises fasting blood glucose levels in SUR-1 -/- mice without affecting glucose tolerance |
參考文獻：
1. Calabria AC, et al. GLP-1 receptor antagonist exendin-(9-39) elevates fasting blood glucose levels in congenital owing to inactivating mutations in the ATP-sensitive K+ channel. Diabetes. 2012 Oct;61(10):2585-91. 2. De León DD, et al. Exendin-(9-39) corrects fasting hypoglycemia in SUR-1-/- mice by lowering cAMP in pancreatic beta-cells and inhibiting secretion. J Biol Chem. 2008 Sep 19;283(38):25786-93. |
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溶解性：
H2O : 50 mg/mL (14.84 mM; Need ultrasonic) |
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保存條件：
-20℃ |
配置溶液濃度參考：
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1mg |
5mg |
10mg |
| 1 mM |
0.297 ml |
1.484 ml |
2.968 ml |
| 5 mM |
0.059 ml |
0.297 ml |
0.594 ml |
| 10 mM |
0.03 ml |
0.148 ml |
0.297 ml |
| 50 mM |
0.006 ml |
0.03 ml |
0.059 ml |
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| 注意： |
部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
上海工商
危險品化學品經營許可證（不帶存儲）
營業執照(三證合一)
北京