貨號	規(guī)格	價格	上海	北京	武漢	南京
S82887-1mg	98.0%	￥500.00 S82887-1mg ￥500.00 現(xiàn)貨	10 10	-	-	-
S82887-5mg	98.0%	￥790.00 S82887-5mg ￥790.00 現(xiàn)貨	8 8	-	-	-
S82887-10mg	98.0%	￥990.00 S82887-10mg ￥990.00 現(xiàn)貨	5 5	-	-	-
S82887-50mg	98.0%	￥1350.00 S82887-50mg ￥1350.00 現(xiàn)貨	3 3	-	-	-

產(chǎn)品介紹

Telacebec (Q203, IAP6) 是一種新型抗結(jié)核藥物，通過抑制分枝桿菌細(xì)胞色素 bc1 復(fù)合物來靶向結(jié)核分枝桿菌（Mycobacterium tuberculosis）細(xì)胞能量的產(chǎn)生。Telacebec 對結(jié)核分枝桿菌 H37Rv 具有活性，在培養(yǎng)基中的 MIC50 為 2.7 nM

產(chǎn)品描述：

靶點：

Mycobacterium tuberculosis H37Rv:2.7 nM(MIC50);Antibacterial;?Antibiotic

體外研究：

Telacebec (Q203) inhibits the growth of MDR and XDR M. tuberculosis clinical isolates in culture broth medium in the low nanomolar range.

體內(nèi)研究：

Telacebec (Q203) is efficacious in a mouse model of tuberculosis at a dose less than 1 mg/kg body weight and displays pharmacokinetic and safety profiles compatible with once-daily dosing.

細(xì)胞實驗：

Cell lines: Raw 264.7 cells Concentrations: 0.1 nM-100 μM Incubation Time: -- Method: Telacebec (Q203) are incubated with macrophages previously. Raw 264.7 cells (American Type Culture Collection TIB-71) were infected with M. tuberculosis H37Rv-GFP at a multiplicity of infection of 2:1 and dispensed into plates. After 5 d of infection, macrophages were stained with Syto 60 for Image acquisition.

動物實驗：

Animal Models: A high dose of M. tuberculosis H37Rv infected-acute tuberculosis BALB/c mouse model Dosages: 0.4, 2, 10 mg/kg Administration: Oral gavage

參考文獻(xiàn)：

1. Veronique R de Jager, et al. Telacebec (Q203), a New Antituberculosis Agent. N Engl J Med. 2020 Mar 26;382(13):1280-1281. 2. Kevin Pethe, et al. Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. Nat Med. 2013 Sep;19(9):1157-60.

溶解性：

Soluble in DMSO、Ethanol

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.795 ml	8.977 ml	17.953 ml
5 mM	0.359 ml	1.795 ml	3.591 ml
10 mM	0.18 ml	0.898 ml	1.795 ml
50 mM	0.036 ml	0.18 ml	0.359 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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Q203

6-chloro-2-ethyl-N-[(4-{4-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}phenyl)methyl]imidazo[1,2-a]pyridine-3-carboxamide