貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S82849-10mg	99.8%	￥60.00 S82849-10mg ￥60.00 現(xiàn)貨	9724 >10	-	-	-
S82849-50mg	99.8%	￥120.00 S82849-50mg ￥120.00 現(xiàn)貨	1947 >10	-	-	-
S82849-100mg	99.8%	￥180.00 S82849-100mg ￥180.00 現(xiàn)貨	979 >10	-	-	-
S82849-1g	≥99%	￥350.00 S82849-1g ￥350.00 現(xiàn)貨	97 >10	-	-	-

產(chǎn)品介紹

Lercanidipine is a calcium channel blocker of the dihydropyridine class.

產(chǎn)品描述：

Lercanidipine is a calcium channel blocker of the dihydropyridine class.

靶點(diǎn)：

Calcium Channel;CalciumChannel

體內(nèi)研究：

In chronically catheterised dogs with experimental renovascular hypertension, lercanidipine decreases diastolic blood pressure in a dose-dependent manner (ED25 = 0.9 mg/kg p.o). In the same animals, long term application of lercanidipine showed permanent decrease of diastolic blood pressure indicating no tolerance of the antihypertensive effect. Lercanidipine possesses significant anticonvulsant effect. It does not affect the muscle coordination or locomotor activity in mice[5]. In clinical studies, lercanidipine has a 24-hour antihypertensive effect and causes no significant increase in heart rate. Lercanidipine has been shown to be effective in a wide range of hypertensive patients, including mild-to-moderate hypertension, severe hypertension, the elderly, and those with isolated systolic hypertension. It is associated with a low rate of adverse events

細(xì)胞實(shí)驗(yàn)：

Cells are incubated for 24 hours in DMEM+EFAF 0.2% and lercanidipine, then with lercanidipine and AcLDL for 24 hours. In the last 2 hours [14C]-oleic acid albumin complex is added for the determination of cholesterol esterification (ACAT activity). (Only for Reference)

參考文獻(xiàn)：

1.Shereen M. Tawakkol, et al. Analytical Chemistry Letters. 2014, 4:255-266. 2.Epstein M, et al. Heart Dis. 2001, 3(6):398-407. 3.Selvaraj N, et al. J Clin Diagn Res. 2015, 9(11):FF01-5. 4.Gasser R, et al. Journal of Clinical and Basic Cardiology. 1999, 2(2):169-174. 5.Canavesi M, et al. J Cardiovasc Pharmacol. 2004, 44(4):416-422.

溶解性：

DMSO:64.8 mg/mL (100 mM) Ethanol:6.5 mg/mL (10 mM)

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.522 ml	7.608 ml	15.216 ml
5 mM	0.304 ml	1.522 ml	3.043 ml
10 mM	0.152 ml	0.761 ml	1.522 ml
50 mM	0.03 ml	0.152 ml	0.304 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

質(zhì)檢證書(shū)(COA)

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批號(hào)：JS298415 貨號(hào)：S20001-25g
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Lercanidipine hydrochloride hemihydrate