貨號	規格	價格	上海	北京	武漢	南京	購買數量
S82848-10mg	99.9%	￥850.00 S82848-10mg ￥850.00 現貨	6 6	-	-	-
S82848-50mg	99.9%	￥2600.00 S82848-50mg ￥2600.00 現貨	3 3	-	-	-

產品介紹

YS-49 is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1. YS-49 is also an isoquinoline compound alkaloid, has a strong positive inotropic action through activation of cardiac β-adrenoceptors

產品描述：

靶點：

Akt;PI3K;Angiotensin Receptor;Adrenergic Receptor;RAAS;?Akt;?PI3K;?AdrenergicReceptor

體內研究：

YS-49 (5?mg/kg; intraperitoneal injection; 8 hours; male Sprague Dawley rats) treatment significantly reduces serum NOx levels in LPS-treated rats, the NOx levels reduce from 86 μM to 34 μM

參考文獻：

1. Sun JJ, Kim HJ, Seo HG, et al. YS49,1-(alpha-naphtylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,regulates angiotensin II-stimulated ROS production, JNK phosphorylation and vascular smooth muscle cell proliferation via the induction of heme oxygen 2. Kang YJ, et al. Prevention of the expression of inducible nitric oxide synthase by a novel positive inotropic agent, YS 49, in rat vascular smooth muscle and RAW 264.7 macrophages. Br J Pharmacol. 1999 Sep;128(2):357-64. 3. Hsu YH, et al. RhoA-mediated inhibition of vascular endothelial cell mobility: positive feedback through reduced cytosolic p21 and p27. J Cell Physiol. 2014 Oct;229(10):1455-65.

溶解性：

DMSO : 100 mg/mL (258.88 mM; Need ultrasonic) H2O : 10 mg/mL (25.89 mM; ultrasonic and warming and heat to 60°C)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.473 ml	12.367 ml	24.734 ml
5 mM	0.495 ml	2.473 ml	4.947 ml
10 mM	0.247 ml	1.237 ml	2.473 ml
50 mM	0.049 ml	0.247 ml	0.495 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻(1篇)

1. [IF=4.8] Xian-Heng Zhang et al."Chinese herbal medicines and its active ingredient wogonin can improve immune inflammation in psoriatic arthritis."INTERNATIONAL IMMUNOPHARMACOLOGY.2025 Feb;147:113984

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