貨號	規格	價格	上海	北京	武漢	南京
S82798-1mg	99.4%	￥255.00 S82798-1mg ￥255.00 現貨	9 9	-	-	-
S82798-2mg	99.4%	￥410.00 S82798-2mg ￥410.00 現貨	8 8	-	-	-
S82798-5mg	99.4%	￥612.00 S82798-5mg ￥612.00 現貨	8 8	-	-	-
S82798-10mg	99.4%	￥1020.00 S82798-10mg ￥1020.00 現貨	6 6	-	-	-
S82798-25mg	99.4%	￥2040.00 S82798-25mg ￥2040.00 現貨	5 5	-	-	-
S82798-50mg	99.4%	￥3145.00 S82798-50mg ￥3145.00 現貨	5 5	-	-	-
S82798-100mg	≥99%	￥5950.00 S82798-100mg ￥5950.00 2-3天	0 貨期：2-3天	-	-	-

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產品介紹

AA26-9 is a potent and broad spectrum serine hydrolase inhibitor. AA26-9 targets included serine peptidases, lipases, amidases, esterases, and thioesterases. AA26-9 shows inhibitory activity against approximately 1/3 of the 40+ serine hydrolases detected in immortalized T cell lines

產品描述：

靶點：

Phospholipase;Phospholipase;?SerineProtease

體外研究：

AA26-9 is synthesized based on a piperazine scaffold shown previously to inhibit serine hydrolases in the context of p-nitrophenoxy carbamate. AA26-9-inhibited enzymes originated from diverse functional subclasses of serine hydrolases, including lipases/phospholipases (AADACL1, ABHD6, ESD, FAAH, PAFAH2, LYPLA3), peptidases (APEH, PRCP, CTSA), thioesterases (LYPLA1, LYPLA2), and uncharacterized enzymes (ABHD11, ABHD13, BAT5). AA26-9 inhibits one of its enzyme targets LYPLA1 by covalent carbamoylation of the enzyme’s serine nucleophile (S114). AA26-9 inhibits 1/3 of the over 40 serine hydrolase found in T-cells

參考文獻：

1. Adibekian A, et al. Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors. Nat Chem Biol. 2011 May 15;7(7):469-78. 2. Borne AL, et al. Deciphering T Cell Immunometabolism with Activity-Based Protein Profiling. Curr Top Microbiol Immunol. 2019;420:175-210.

溶解性：

Soluble in DMSO、H2O

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	6.018 ml	30.088 ml	60.176 ml
5 mM	1.204 ml	6.018 ml	12.035 ml
10 mM	0.602 ml	3.009 ml	6.018 ml
50 mM	0.12 ml	0.602 ml	1.204 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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