貨號	規(guī)格	價格	上海	北京	武漢	南京
S82792-1mg	≥98%	￥580.00 S82792-1mg ￥580.00 2-3天	0 貨期：2-3天	-	-	-
S82792-5mg	≥98%	￥1750.00 S82792-5mg ￥1750.00 2-3天	0 貨期：2-3天	-	-	-
S82792-10mg	≥98%	￥2600.00 S82792-10mg ￥2600.00 2-3天	0 貨期：2-3天	-	-	-
S82792-25mg	≥98%	￥4300.00 S82792-25mg ￥4300.00 2-3天	0 貨期：2-3天	-	-	-
S82792-50mg	≥98%	￥6900.00 S82792-50mg ￥6900.00 2-3天	0 貨期：2-3天	-	-	-
S82792-100mg	≥98%	￥11500.00 S82792-100mg ￥11500.00 2-3天	0 貨期：2-3天	-	-	-

大包裝詢價收藏產品

加入購物車

到貨通知，提交手機號入庫后將短信通知。

產品介紹

BIX 02565 is a potent ribosomal S6 kinase 2 (RSK2) inhibitor with IC50 of 1.1 nM

產品描述：

BIX 02565 is a potent ribosomal S6 kinase 2 (RSK2) inhibitor with IC50 of 1.1 nM

靶點：

IC50: 1.1 nM (RSK2);LRRK2;?S6Kinase

體外研究：

BIX 02565, a potent RSK2 inhibitor (IC50=1.1 nM) targets for the treatment of heart failure secondary to myocardial infarction through indirect NHE inhibition. BIX 02565, a second Rsk inhibitor, protects enzyme active sites from reaction with biotinylated nucleotide acyl phosphates

體內研究：

In telemetry-instrumented rats, BIX 02565 (30, 100, and 300 mg/kg p.o. QD for 4 days) elicits concentration-dependent decreases in MAP after each dose (to -39±4 mm Hg on day 4 at Tmax). BIX 02565 produces concentration-dependent relaxation ex vivo in the phenylephrine-constricted rat aortic ring at concentrations above 0.03 μM with a calculated EC50 of 3.1 μM. Subsequently, BIX 02565 is infused in the anesthetized rat in a low-dose (0.1, 0.3, and 1.0 mg/kg per 20 min) and high-dose (1.0, 3.0, and 10.0 mg/kg per 20 min) series of continuous infusions to test the effect of compound on hemodynamics in vivo

參考文獻：

1. Fryer RM, et al. Mitigation of off-target adrenergic binding and effects on cardiovascular function in the discovery of novel ribosomal S6 kinase 2 inhibitors. Journal of Pharmacology and Experimental Therapeutics (2012), 340(3), 492-500. 2. Edgar AJ, et al. A combination of SILAC and nucleotide acyl phosphate labelling reveals unexpected targets of the Rsk inhibitor BI-D1870. Biosci Rep. 2013 Dec 17.

溶解性：

soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.181 ml	10.904 ml	21.808 ml
5 mM	0.436 ml	2.181 ml	4.362 ml
10 mM	0.218 ml	1.09 ml	2.181 ml
50 mM	0.044 ml	0.218 ml	0.436 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

質檢證書(COA)

輸入產品批號：

如何獲取質檢證書(COA)?

請輸入貨號和一個與之匹配的批號。
例如:
批號：JS298415 貨號：S20001-25g
在貨品標簽上如何找到貨號和批號?

摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

質量

濃度

體積

分子摩爾量

計算重置

玖玖资源网站,爆乳久久久,日韩精品乱码久久久蜜桃,精品呦国产一区二区三区,国产伦高清一区二区三区,sese一区二区,午夜精品福利一区二区三区,三级黄色网站久久免费