貨號	規(guī)格	價格	上海	北京	武漢	南京
S82705-5mg	≥99%	￥660.00 S82705-5mg ￥660.00 2-3天	0 貨期：2-3天	-	-	-
S82705-10mg	≥99%	￥990.00 S82705-10mg ￥990.00 2-3天	0 貨期：2-3天	-	-	-
S82705-50mg	≥99%	￥2700.00 S82705-50mg ￥2700.00 2-3天	0 貨期：2-3天	-	-	-
S82705-100mg	≥99%	￥4500.00 S82705-100mg ￥4500.00 2-3天	0 貨期：2-3天	-	-	-

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產(chǎn)品介紹

Ro 41-1049 hydrochloride is a reversible and selective inhibitor of monoamine oxidase-A (MAO-A). An homogeneous population of high affinity binding sites for [3H]Ro 41-1049 is found in membrane preparations from human frontal cortex and placenta (Kd values of 16.5 and 64.4 nM, respectively)

產(chǎn)品描述：

靶點：

MAO-A;MAO

體內研究：

Ro 41-1049 (1-50 mg/kg; intraperitoneal injection; for 3 hours; Sprague-Dawley rats) treatment inhibits dopamine metabolite formation and increases dopamine levels in a dose-dependent fashion. Pretreatment with Ro 41-1049 (20 mg/kg) significantly increases dopamine formation following L-dopa administration (100 mg/kg IP) while decreasing formation of 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA). Animal Model: Sprague-Dawley rats (200-240 g) Dosage: 1 mg/kg, 5 mg/kg, 10 mg/kg, 20 mg/kg, or 50 mg/kg Administration: Intraperitoneal injection; for 3 hours Result: Inhibited dopamine metabolite formation and increased dopamine levels in a dose-dependent fashion. Pretreatment with the concentration of 20 mg/kg significantly increased dopamine formation following L-dopa administration while decreasing formation of DOPAC and HVA.

參考文獻：

1. Cesura AM, et al. Characterization of the binding of [3H]Ro 41-1049 to the active site of human monoamine oxidase-A. Mol Pharmacol. 1990 Mar;37(3):358-66. 2. Brannan T, et al. Effect of a selective MAO-A inhibitor (Ro 41-1049) on striatal L-dopa and dopamine metabolism: an in vivo study. J Neural Transm Park Dis Dement Sect. 1994;8(1-2):99-105.

溶解性：

Soluble in DMSO、H2O

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.314 ml	16.569 ml	33.138 ml
5 mM	0.663 ml	3.314 ml	6.628 ml
10 mM	0.331 ml	1.657 ml	3.314 ml
50 mM	0.066 ml	0.331 ml	0.663 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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Ro 41-1049 (hydrochloride)