貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京	購買數(shù)量
S82687-5mg	≥99%	￥1730.00 S82687-5mg ￥1730.00 2-3天	0 貨期：2-3天	-	-	-
S82687-10mg	≥99%	￥2750.00 S82687-10mg ￥2750.00 2-3天	0 貨期：2-3天	-	-	-

產(chǎn)品介紹

YLF-466D is a newly developed AMPK activator, which inhibits platelet aggregation.

產(chǎn)品描述：

YLF-466D is a newly developed AMPK activator, which inhibits platelet aggregation.

靶點(diǎn)：

AMPK

體外研究：

The effect of YLF-466D on platelet AMPK and aggregation are examined to test whether YLF-466D can stimulate AMPK in platelets and thereby suppress aggregation. Platelet AMPK is activated by YLF-466D, which is confirmed with activation-dependent phosphorylation at Thr172. Consistent with this result, YLF-466D inhibits platelet aggregation induced by thrombin. Such inhibition is observed in the aggregation elicited by ADP and collagen as well as thrombin, indicating that the antiaggregatory effect of YLF-466D is not platelet-agonist specific but common, regardless of agonist type. All the effects on AMPK and aggregation are concentration-dependent with the highest efficacy at 150 μM. IC50 against thrombin-, ADP- and collagen-induced aggreation are approximately 84, 55 and 87 μM, respectively

參考文獻(xiàn)：

1. Liu Y, et al. Antiplatelet effect of a newly developed AMP-activated protein kinase activator YLF-466D. Eur J Pharmacol. 2015 Aug 5;760:81-7.

溶解性：

soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.146 ml	10.731 ml	21.463 ml
5 mM	0.429 ml	2.146 ml	4.293 ml
10 mM	0.215 ml	1.073 ml	2.146 ml
50 mM	0.043 ml	0.215 ml	0.429 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

質(zhì)檢證書(COA)

輸入產(chǎn)品批號(hào)：

如何獲取質(zhì)檢證書(COA)?

請輸入貨號(hào)和一個(gè)與之匹配的批號(hào)。
例如:
批號(hào)：JS298415 貨號(hào)：S20001-25g
在貨品標(biāo)簽上如何找到貨號(hào)和批號(hào)?

摩爾濃度計(jì)算器

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

質(zhì)量

濃度

體積

分子摩爾量

計(jì)算重置

玖玖资源网站,爆乳久久久,日韩精品乱码久久久蜜桃,精品呦国产一区二区三区,国产伦高清一区二区三区,sese一区二区,午夜精品福利一区二区三区,三级黄色网站久久免费