貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S82597-5mg	≥98%	￥260.00 S82597-5mg ￥260.00 2-3天	0 貨期：2-3天	-	-	-
S82597-50mg	99.9%	￥980.00 S82597-50mg ￥980.00 現(xiàn)貨	6 6	-	-	-
S82597-100mg	99.9%	￥1580.00 S82597-100mg ￥1580.00 現(xiàn)貨	3 3	-	-	-
S82597-500mg	≥98%	￥5000.00 S82597-500mg ￥5000.00 2-3天	0 貨期：2-3天	-	-	-

產(chǎn)品介紹

Bepotastine is a selective and orally active second-generation histamine H1 receptor antagonist, can suppress the expression of nerve growth factor (NGF). Bepotastine has the potential for allergic rhinitis, allergic conjunctivitis and urticaria/pruritus research

產(chǎn)品描述：

靶點(diǎn)：

Histamine H1 Receptor;Others;?HistamineReceptor

體內(nèi)研究：

Bepotastine (10 g/L; eye drop; 3 times at intervals of 20 min in one eye) demonstrates significant inhibition of PAF-induced conjunctival eosinophil infiltration. Bepotastine (3 mg/kg; p.o.; once) suppresses scratching behavior to a frequency of 59.0 and a duration of 14.57 seconds, which are almost the same levels compares with the control. Bepotastine (10 mg/kg; p.o.; once) significantly suppresses serum LTB 4 levels to 711.3 pg/mL at 1 h and 858.8 pg/mL at 2 h in NC/Nga mice with a rash

參考文獻(xiàn)：

1. Kida T, et al. Bepotastine besilate, a highly selective histamine H(1) receptor antagonist, suppresses vascular hyperpermeability and eosinophil recruitment in in vitro and in vivo experimental allergic conjunctivitis models. Exp Eye Res. 2010 Jul;91(1):8 2. Kamata Y, et al. Bepotastine besilate downregulates the expression of nerve elongation factors in normal human epidermal keratinocytes. J Dermatol Sci. 2018 Apr 23:S0923-1811(18)30186-5. 3. Tanizaki H, et al. Oral administration of bepotastine besilate suppressed scratching behavior of atopic dermatitis model NC/Nga mice. Int Arch Allergy Immunol. 2008;145(4):277-82. 4. Jon I Williams, et al. Non-clinical pharmacology, pharmacokinetics, and safety findings for the antihistamine bepotastine besilate. Curr Med Res Opin. 2010 Oct;26(10):2329-38.

溶解性：

Soluble in H2O、DMSO

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.571 ml	12.857 ml	25.714 ml
5 mM	0.514 ml	2.571 ml	5.143 ml
10 mM	0.257 ml	1.286 ml	2.571 ml
50 mM	0.051 ml	0.257 ml	0.514 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

質(zhì)檢證書(COA)

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批號(hào)：JS298415 貨號(hào)：S20001-25g
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BEPOTASTINE