貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S82242-5mg	99.5%	￥680.00 S82242-5mg ￥680.00 現(xiàn)貨	8 8	-	-	-
S82242-10mg	99.5%	￥1275.00 S82242-10mg ￥1275.00 現(xiàn)貨	6 6	-	-	-
S82242-50mg	99.5%	￥3600.00 S82242-50mg ￥3600.00 現(xiàn)貨	3 3	-	-	-

產(chǎn)品介紹

Resminostat hydrochloride is a potent inhibitor of HDAC1, HDAC3 and HDAC6, with mean IC50 values of 42.5, 50.1, 71.8 nM, respectively, and shows less potent activities against HDAC8, with an IC50 of 877 nM.

產(chǎn)品描述：

靶點(diǎn)：

HDAC1：42.5 nM (IC50)；HDAC3：50.1 nM (IC50)；HDAC6：71.8 nM (IC50)；HDAC8：877 nM (IC50);HDAC

體外研究：

Resminostat hydrochloride (Resminostat [HCl], 5 μM) induces histone acetylation in myeloma cells. Resminostat hydrochloride displays a substrate competitive binding mode with a mean Ki value of 27 nM. Resminostat hydrochloride (5 μM) induces histone hyperacetylation in myeloma cells. Resminostat inhibits cell growth, induces apoptosis and inhibits MM cell proliferation. Resminostat (5 μM) also modulates expression of bcl-2 family proteins and inhibits Akt pathway signalling downstream of Akt. Resminostat exerts synergistic activity against myeloma cells when combined with common and new anti-myeloma agents. Resminostat inhibits cell growth in head and neck squamous cell carcinoma cell lines, with IC50s ranging from 0.775 μM to 1.572 μM (IC50 for SCC25: 0.775 μM; CAL27: 1.572 μM; and FaDu: 0.899 μM). Resminostat (1.25 and 2.5 μM) has a synergistic effect with irradiation on HNSCC cell lines. Resminostat in combination with cisplatin induces a downregulation of survivin. However, Resminostat shows no effect on Mcl-1 and p-AKT expression. Resminostat reduces viability of HCC cells with the co-treatment of AZD-2014, with IC50s ranging from 0.89 ± 0.12 μM to 0.07 ± 0.01 μM

參考文獻(xiàn)：

1. Mandl-Weber S, et al. The novel inhibitor of histone deacetylase resminostat (RAS2410) inhibits proliferation and induces apoptosis in multiple myeloma (MM) cells. Br J Haematol. 2010 May;149(4):518-28. 2. Enzenhofer E, et al. Effect of the histone deacetylase inhibitor resminostat on head and neck squamous cell carcinoma cell lines. Head Neck. 2017 May;39(5):900-907. 3. Peng X, et al. mTOR inhibition sensitizes human hepatocellular carcinoma cells to resminostat. Biochem Biophys Res Commun. 2016 Sep 2;477(4):556-562.

溶解性：

Soluble in DMSO、H2O

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.592 ml	12.958 ml	25.916 ml
5 mM	0.518 ml	2.592 ml	5.183 ml
10 mM	0.259 ml	1.296 ml	2.592 ml
50 mM	0.052 ml	0.259 ml	0.518 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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Resminostat (hydrochloride)