貨號	規格	價格	上海	北京	武漢	南京
S82107-1mg	99.8%	￥246.00 S82107-1mg ￥246.00 現貨	9010 >10	-	-	-
S82107-5mg	99.8%	￥425.00 S82107-5mg ￥425.00 現貨	1805 >10	-	-	-
S82107-10mg	99.8%	￥650.00 S82107-10mg ￥650.00 現貨	906 >10	-	-	-
S82107-25mg	99.8%	￥1080.00 S82107-25mg ￥1080.00 現貨	366 >10	-	-	-
S82107-50mg	99.8%	￥1630.00 S82107-50mg ￥1630.00 現貨	185 >10	-	-	-
S82107-100mg	99.8%	￥2400.00 S82107-100mg ￥2400.00 現貨	95 >10	-	-	-

產品介紹

J-147 is an exceptionally potent, orally active, neuroprotective agent for cognitive enhancement. J-147 can readily pass the blood brain barrier (BBB). J-147 can inhibit monoamine oxidase B (MAO B) and the dopamine transporter with EC50 values of 1.88 μM and 0.649 μM, respectively. J-147 has potential for the treatment of Alzheimer’s disease (AD)

產品描述：

靶點：

MAO B; Dopamine transporter;EpigeneticReaderDomain;?DopamineReceptor;?MonoamineOxidase

體外研究：

J-147 promotes HT22 and primary cell survival in a dose-dependent manner (EC50 value range of 0.06-0.115 μM)

體內研究：

J-147 (diet is prepared by the addition of J-147 at 200ppm; 6 months) enhances memory and dendritic spine number in old mice. The half life (t1/2) of J-147 is calculated at 1.5 hrs in plasma and 2.5 hrs in brain ( per oral (PO) administration at a single dose of 20 mg/kg). Animal Model: 24 male C57Bl/6 mice aged 24 months; using 8 month-old mice as controls Dosage: 200 ppm Administration: The diet was prepared by the addition of 200ppm; 6 months Result: While both young and old animals recognized when an object was moved a large distance (135 degrees), a reduction in the recognition index (RI) in aged mice was observed when the object was moved a smaller distance of 45 degrees. The reduction in the RI was reversed upon treatment with J147.

參考文獻：

1. Wang M, et al. The first synthesis of [11C]J147, a new potential PET agent for imaging of Alzheimer's disease. Bioorg Med Chem Lett. 2013 Jan 15;23(2):524-7. 2. Prior M, et al. The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice. Alzheimers Res Ther. 2013 May 14;5(3):25. 3. Chen Q, et al. A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease. PLoS One. 2011;6(12):e27865. 4. Prior M, et al. Selecting for neurogenic potential as an alternative for Alzheimer's disease drug discovery. Alzheimers Dement. 2016 Jun;12(6):678-86.

溶解性：

soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.854 ml	14.272 ml	28.544 ml
5 mM	0.571 ml	2.854 ml	5.709 ml
10 mM	0.285 ml	1.427 ml	2.854 ml
50 mM	0.057 ml	0.285 ml	0.571 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

質檢證書(COA)

輸入產品批號：

如何獲取質檢證書(COA)?

請輸入貨號和一個與之匹配的批號。
例如:
批號：JS298415 貨號：S20001-25g
在貨品標簽上如何找到貨號和批號?

摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

質量

濃度

體積

分子摩爾量

計算重置

玖玖资源网站,爆乳久久久,日韩精品乱码久久久蜜桃,精品呦国产一区二区三区,国产伦高清一区二区三区,sese一区二区,午夜精品福利一区二区三区,三级黄色网站久久免费