貨號	規格	價格	上海	北京	武漢	南京
S82086-5mg	≥99%	￥1500.00 S82086-5mg ￥1500.00 3-5天	0 貨期：3-5天	-	-	-
S82086-10mg	≥99%	￥2400.00 S82086-10mg ￥2400.00 3-5天	0 貨期：3-5天	-	-	-
S82086-25mg	≥99%	￥4100.00 S82086-25mg ￥4100.00 3-5天	0 貨期：3-5天	-	-	-
S82086-100mg	≥99%	￥8100.00 S82086-100mg ￥8100.00 3-5天	0 貨期：3-5天	-	-	-

產品介紹

GSK2256294A (GSK 2256294) is a selective and orally active inhibitor of soluble epoxide hydrolase (sEH). GSK2256294A inhibits recombinant human sEH, rat sEH orthologs and murine sEH orthologs with IC50s of 27, 61 and 189 pM, respectively. GSK2256294A can be used for the research of chronic obstructive pulmonary disease (COPD) and cardiovascular disease

產品描述：

靶點：

IC50: 27 pM (recombinant human sEH), 61 pM (rat sEH orthologs), 189 pM (murine sEH orthologs);Others;?EpoxideHydrolase

體外研究：

GSK2256294A (300 pM-10 μM; 2 h) inhibits the conversion of 14,15-EET-d11 to 14,15-DHET-d11 in human, rat and mouse whole blood.

體內研究：

GSK2256294A (5-30 mg/kg; p.o. twice daily 5 days/week for two weeks) inhibits the generation and maintenance of pulmonary inflammation in cigarette smoke-exposed mice.
GSK2256294A (30 mg/kg; p.o. twice daily for 8 days) decreases pulmonary inflammation in cigarette smoke-exposed mice. Animal Model: Mice exposed to cigarette smoke 5 days/week for 2 weeks Dosage: 5 and 30 mg/kg Administration: Oral gavage; 5 and 30 mg/kg twice daily 5 days/week; for 2 weeks Result: Dose-dependently inhibited numbers of BAL fluid total cells, neutrophils, macrophages and the keratinocyte chemoattractant (KC) levels in lung tissue. Animal Model: Mice exposed to cigarette smoke 5 days/week for 2 weeks Dosage: 30 mg/kg Administration: Oral gavage; 30 mg/kg twice daily; for 8 days Result: Significantly reduced neutrophils, macrophages and pulmonary inflammation in cigarette smoke-exposed mice.

參考文獻：

1. Podolin PL, Bolognese BJ, Foley JF, Long E 3rd, Peck B, Umbrecht S, Zhang X,Zhu P, Schwartz B, Xie W, Quinn C, Qi H, Sweitzer S, Chen S, Galop M, Ding Y,Belyanskaya SL, Israel DI, Morgan BA, Behm DJ, Marino JP Jr, Kurali E, BarnetteMS, Mayer RJ, Booth-Genthe CL, Callahan JF. In vitro and in vivo characterizationof a novel soluble epoxide hydrolase inhibitor. Prostaglandins Other LipidMediat. 2013 Jul-Aug;104-105:25-31. doi: 10.1016/j.prostaglandins.2013.02.001.Epub 2013 Feb 19. PubMed PMID: 23434473.

溶解性：

soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.235 ml	11.174 ml	22.349 ml
5 mM	0.447 ml	2.235 ml	4.47 ml
10 mM	0.223 ml	1.117 ml	2.235 ml
50 mM	0.045 ml	0.223 ml	0.447 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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GSK2256294A

(1R,3S)-N-(4-cyano-2-(trifluoromethyl)benzyl)-3-((4-methyl-6-(methylamino)-1,3,5-triazin-2-yl)amino)cyclohexane-1-carboxamide