貨號	規格	價格	上海	北京	武漢	南京
S82078-5mg	99.03%	￥580.00 S82078-5mg ￥580.00 現貨	10 10	-	-	-
S82078-10mg	99.03%	￥900.00 S82078-10mg ￥900.00 現貨	10 10	-	-	-
S82078-50mg	99.03%	￥3700.00 S82078-50mg ￥3700.00 現貨	2 2	-	-	-

產品介紹

TAK-960 is an orally available, selective inhibitor of polo-like kinase 1 (PLK1), with an IC50 of 0.8 nM. TAK-960 also shows inhibitory activities against PLK2 and PLK3, with IC50s of 16.9 and 50.2 nM, respectively. TAK-960 inhibits proliferation of multiple cancer cell lines and exhibits significant efficacy against multiple tumor xenografts

產品描述：

靶點：

PLK1:0.8 nM (IC50);PLK2:16.9 nM (IC50);PLK3:50.2 nM (IC50);FAK/PTK2:19.6 nM (IC50);MLCK/MYLK:25.6 nM (IC50);FES/FPS:58.2 nM (IC50);PLK

體內研究：

TAK-960 exhibits (10 mg/kg; p.o.; once daily for 2 weeks) significant efficacy against multiple tumor xenografts. In animal models, TAK-960 (p.o.) increases pHH3 in a dose-dependent manner and significantly inhibits the growth of HT-29 colorectal cancer xenografts

參考文獻：

1. Hikichi Y, et al. TAK-960, a novel, orally available, selective inhibitor of polo-like kinase 1, shows broad-spectrum preclinical antitumor activity in multiple dosing regimens. Mol Cancer Ther. 2012 Mar;11(3):700-9. 2. Inoue M, et al. PLK1 blockade enhances therapeutic effects of radiation by inducing cell cycle arrest at the mitotic phase. Sci Rep. 2015 Oct 27;5:15666.

溶解性：

DMSO : 16.67 mg/mL (29.68 mM; ultrasonic and warming and heat to 60°C)

保存條件：

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.781 ml	8.903 ml	17.806 ml
5 mM	0.356 ml	1.781 ml	3.561 ml
10 mM	0.178 ml	0.89 ml	1.781 ml
50 mM	0.036 ml	0.178 ml	0.356 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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