貨號	規格	價格	上海	北京	武漢	南京
S81948-1mg	≥97%	￥340.00 S81948-1mg ￥340.00 2-3天	0 貨期：2-3天	-	-	-
S81948-5mg	≥97%	￥820.00 S81948-5mg ￥820.00 2-3天	0 貨期：2-3天	-	-	-
S81948-10mg	≥97%	￥1400.00 S81948-10mg ￥1400.00 2-3天	0 貨期：2-3天	-	-	-
S81948-25mg	≥97%	￥2900.00 S81948-25mg ￥2900.00 2-3天	0 貨期：2-3天	-	-	-
S81948-50mg	≥97%	￥5600.00 S81948-50mg ￥5600.00 2-3天	0 貨期：2-3天	-	-	-
S81948-100mg	≥97%	￥10800.00 S81948-100mg ￥10800.00 2-3天	0 貨期：2-3天	-	-	-

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產品介紹

Raf inhibitor 1 is a potent Raf kinase inhibitor with Kis of 1 nM, 1 nM, and 0.3 nM for B-RafWT, B-RafV600E, and C-Raf, respectively.

產品描述：

Raf inhibitor 1 is a potent Raf kinase inhibitor with Kis of 1 nM, 1 nM, and 0.3 nM for B-RafWT, B-RafV600E, and C-Raf, respectively.

靶點：

B-Raf:1 nM (Ki);B-RafV600E:1 nM (Ki);c-Raf:0.3 nM (Ki);Raf

體外研究：

Raf inhibitor 1 (Compound 13) inhibits A375 and HCT-116 proliferation with IC50s of 0.31 and 0.72 μM, respectively. Raf inhibitor 1 (Compound 13) binds to and stabilizes B-Raf in a DFG-out, inactive conformation in which the ATP pocket is partially filled by Phe595 and Gly596 from the DFG motif. Raf inhibitor 1 (Compound 13) additionally exhibits low micromolar inhibition against wild type B-Raf cell lines, which may be due to off-target kinase activities or alternatively to pan-Raf inhibition, including Raf dimers

參考文獻：

1. Wang X, et al. Conformation-specific effects of Raf kinase inhibitors. J Med Chem. 2012 Sep 13;55(17):7332-41.

溶解性：

soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.088 ml	10.44 ml	20.88 ml
5 mM	0.418 ml	2.088 ml	4.176 ml
10 mM	0.209 ml	1.044 ml	2.088 ml
50 mM	0.042 ml	0.209 ml	0.418 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

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B-Raf inhibitor 1