貨號	規格	價格	上海	北京	武漢	南京
S81877-5mg	≥98%	￥990.00 S81877-5mg ￥990.00 2-3天	0 貨期：2-3天	-	-	-
S81877-10mg	≥98%	￥1450.00 S81877-10mg ￥1450.00 2-3天	0 貨期：2-3天	-	-	-
S81877-50mg	≥98%	￥5700.00 S81877-50mg ￥5700.00 2-3天	0 貨期：2-3天	-	-	-

產品介紹

Cevimeline hydrochloride (AF102B hydrochloride) is a quinuclidine derivative of acetylcholine and a selective and orally active muscarinic M1 and M3 receptor agonist. Cevimeline hydrochloride stimulates secretion by the salivary glands and can be used as a sialogogue for xerostomia. Cevimeline hydrochloride can cross the blood-brain barrier (BBB)

產品描述：

靶點：

Muscarinic M1 and M3 receptor

體內研究：

Cevimeline (0.008-0.016 mg/kg; intraperitoneal injection; male Wistar rats) treatment shows slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response. Cevimeline inhibits angiotensin II-induced water intake and neuronal activity in the subfornical organ at 0.016 mg/kg

參考文獻：

1. Witsell DL, et al. Effectiveness of cevimeline to improve oral health in patients with postradiation xerostomia.Head Neck. 2012 Aug;34(8):1136-42. doi: 10.1002/hed.21894. Epub 2012 Jan 9. 2. Kondo Y, et al.Cevimeline-induced monophasic salivation from the mouse submandibular gland: decreased Na+ content in saliva results from specific and early activation of Na+/H+ exchange.J Pharmacol Exp Ther. 2011 Apr;337(1):267-74. Epub 2011 Jan 14. 3. Ono K, et al. Distinct effects of cevimeline and pilocarpine on salivary mechanisms, cardiovascular response and thirst sensation in rats.Arch Oral Biol. 2012 Apr;57(4):421-8. Epub 2011 Nov 17. 4. Voskoboynik B, et al.Cevimeline (Evoxac) overdose.J Med Toxicol. 2011 Mar;7(1):57-9. 5. Mitoh Y, et al. Effects of cevimeline on excitability of parasympathetic preganglionic neurons in the superior salivatory nucleus of rats. Auton Neurosci. 2017 Sep;206:1-7.

溶解性：

Soluble in H2O

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	4.241 ml	21.207 ml	42.413 ml
5 mM	0.848 ml	4.241 ml	8.483 ml
10 mM	0.424 ml	2.121 ml	4.241 ml
50 mM	0.085 ml	0.424 ml	0.848 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

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濃度

體積

分子摩爾量

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Cevimeline Hydrochloride Salt