貨號	規(guī)格	價格	上海	北京	武漢	南京
S81788-5mg	≥98%	￥530.00 S81788-5mg ￥530.00 2-3天	0 貨期：2-3天	-	-	-
S81788-10mg	≥98%	￥1000.00 S81788-10mg ￥1000.00 2-3天	0 貨期：2-3天	-	-	-
S81788-50mg	≥98%	￥3600.00 S81788-50mg ￥3600.00 2-3天	0 貨期：2-3天	-	-	-
S81788-100mg	≥98%	￥6200.00 S81788-100mg ￥6200.00 2-3天	0 貨期：2-3天	-	-	-

產(chǎn)品介紹

Tirbanibulin (dihydrochloride) (KX2-391 (dihydrochloride)) is an inhibitor of Src that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines.

產(chǎn)品描述：

Tirbanibulin (dihydrochloride) (KX2-391 (dihydrochloride)) is an inhibitor of Src that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines.

靶點：

GI50: 9 nM (Src HuH7), 13 nM (Src PLC/PRF/5), 26 nM (Src Hep3B), 60 nM (Src HepG2);Src

體外研究：

Tirbanibulin (KX2-391) is a Src inhibitor that is directed to the Src substrate pocket. KX2-391 shows steep dose-response curves against Huh7 (GI50=9 nM), PLC/PRF/5 (GI50=13 nM), Hep3B (GI50=26 nM), and HepG2 (GI50=60 nM), four hepatic cell cancer (HCC) cell lines. Tirbanibulin (KX2-391) is found to inhibit certain leukemia cells that are resistant to current commercially available drugs, such as those derived from chronic leukemia cells with the T3151 mutation. Tirbanibulin (KX2-391) is evaluated in engineered Src driven cell growth assays inNIH3T3/c-Src527F and SYF/c-Src527F cells and exhibits GI50 with 23 nM and 39 nM, respectively

體內(nèi)研究：

Orally administered Tirbanibulin (KX2-391) is shown to inhibit primary tumor growth and to suppress metastasis, in pre-clinical animal models of cancer

參考文獻(xiàn)：

1. Lau GM, et al. Expression of Src and FAK in hepatocellular carcinoma and the effect of Src inhibitors on hepatocellular carcinoma in vitro. Dig Dis Sci, 2009, 54(7), 1465-1474. 2. Fallah-Tafti A, et al. Thiazolyl N-benzyl-substituted acetamide derivatives: synthesis, Src kinase inhibitory and anticancer activities. Eur J Med Chem, 2011, 46(10), 4853-4858.

溶解性：

Soluble in DMSO、H2O

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.982 ml	9.912 ml	19.824 ml
5 mM	0.396 ml	1.982 ml	3.965 ml
10 mM	0.198 ml	0.991 ml	1.982 ml
50 mM	0.04 ml	0.198 ml	0.396 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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KX2-391 (dihydrochloride)