貨號	規(guī)格	價格	上海	北京	武漢	南京
S81772-1mg	99.3%	￥120.00 S81772-1mg ￥120.00 現(xiàn)貨	10 10	-	-	-
S81772-2mg	99.3%	￥180.00 S81772-2mg ￥180.00 現(xiàn)貨	10 10	-	-	-
S81772-5mg	99.3%	￥280.00 S81772-5mg ￥280.00 現(xiàn)貨	7 7	-	-	-
S81772-10mg	99.3%	￥450.00 S81772-10mg ￥450.00 現(xiàn)貨	6 6	-	-	-
S81772-25mg	99.3%	￥800.00 S81772-25mg ￥800.00 現(xiàn)貨	5 5	-	-	-
S81772-50mg	≥99%	￥1100.00 S81772-50mg ￥1100.00 2-3天	0 貨期：2-3天	-	-	-
S81772-100mg	≥99%	￥1800.00 S81772-100mg ￥1800.00 2-3天	0 貨期：2-3天	-	-	-

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產(chǎn)品介紹

HPGDS inhibitor 1 is a potent, selective and orally active Hematopoietic Prostaglandin D Synthase (HPGDS) inhibitor with an IC50s of 0.6 nM and 32 nM in enzyme and cellular assays, respectively. HPGDS inhibitor 1 does not inhibit human L-PGDS, mPGES, COX-1, COX-2, or 5-LOX

產(chǎn)品描述：

靶點：

IC50: 0.6 nM (HPGDS in enzyme assays) and 32 nM (HPGDS in cellular assays);PGESynthase

體外研究：

HPGDS inhibitor 1 has equal potency against purified HPGDS from human, rat, dog, and sheep (IC50, 0.5-2.3 nM)

體內(nèi)研究：

HPGDS inhibitor 1 (compound 8; 1 mg/kg) has excellent PK characteristics with 76% bioavailability, and the T1/2 is 4.1 hours in rats. Rats dosed orally with 1 mg/kg and 10 mg/kg HPGDS inhibitor 1 (compound 8) are sacrificed at various times. Oral administration of HPGDS inhibitor 1 blocks PGD2 production in the rat spleen; inhibition of PGD2 is inversely correlated with the plasma concentration of HPGDS inhibitor 1 in a time- and dose-dependent manner. HPGDS inhibitor 1 (compound 8; 1 mg/mL) illustrates efficacy in an in vivo sheep model of asthma

參考文獻(xiàn)：

1. Chris P Carron, et al. Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS). ACS Med Chem Lett. 2010 Feb 2;1(2):59-63.

溶解性：

soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.622 ml	13.111 ml	26.221 ml
5 mM	0.524 ml	2.622 ml	5.244 ml
10 mM	0.262 ml	1.311 ml	2.622 ml
50 mM	0.052 ml	0.262 ml	0.524 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

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