貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S81753-1mg	99.9%	￥190.00 S81753-1mg ￥190.00 現(xiàn)貨	5 5	-	-	-
S81753-2mg	99.9%	￥245.00 S81753-2mg ￥245.00 現(xiàn)貨	5 5	-	-	-
S81753-5mg	99.9%	￥290.00 S81753-5mg ￥290.00 現(xiàn)貨	5 5	-	-	-
S81753-10mg	99.9%	￥430.00 S81753-10mg ￥430.00 現(xiàn)貨	6 6	-	-	-
S81753-25mg	99.9%	￥650.00 S81753-25mg ￥650.00 現(xiàn)貨	6 6	-	-	-
S81753-50mg	≥98%	￥1100.00 S81753-50mg ￥1100.00 2-3天	0 貨期：2-3天	-	-	-

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產(chǎn)品介紹

GNE-477 is a potent and efficacious dual PI3K (IC50=4 nM)/mTOR(Ki=21 nM) inhibitor.

產(chǎn)品描述：

GNE-477 is a potent and efficacious dual PI3K (IC50=4 nM)/mTOR(Ki=21 nM) inhibitor.

靶點(diǎn)：

PI3Kα:4 nM (IC50);mTOR:21 nM (Ki);PI3K;?mTOR

體外研究：

GNE-477 (Compound 8) has improved potency in the MCF7.1 cell proliferation assay with an EC50 of 143 nM

體內(nèi)研究：

GNE-477 also exhibits stasis in a PC3 tumor growth inhibition study. In an experiment evaluating the tumor growth inhibition of a PC3 tumor xenograft over 14 days, stasis is achieved at a 20 mg/kg QD dose and significant inhibition is observed with doses as low as 1 mg/kg QD. GNE-477 is generally well tolerated during this study as demonstrated by acceptable levels of weight loss comparable to that observed with the animals in the vehicle cohort

參考文獻(xiàn)：

1. Heffron TP, et al. Identification of GNE-477, a potent and efficacious dual PI3K/mTOR inhibitor. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2408-11.

溶解性：

soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.982 ml	9.908 ml	19.817 ml
5 mM	0.396 ml	1.982 ml	3.963 ml
10 mM	0.198 ml	0.991 ml	1.982 ml
50 mM	0.04 ml	0.198 ml	0.396 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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