貨號	規格	價格	上海	北京	武漢	南京
S81688-1mg	98.1%	￥180.00 S81688-1mg ￥180.00 現貨	10 10	-	-	-
S81688-5mg	98.1%	￥410.00 S81688-5mg ￥410.00 現貨	10 10	-	-	-
S81688-10mg	98.1%	￥570.00 S81688-10mg ￥570.00 現貨	8 8	-	-	-
S81688-50mg	98.1%	￥1880.00 S81688-50mg ￥1880.00 現貨	7 7	-	-	-
S81688-100mg	≥98%	￥2970.00 S81688-100mg ￥2970.00 2-3天	0 貨期：2-3天	-	-	-

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產品介紹

Esonarimod is an antirheumatic drug.

產品描述：

Esonarimod is an antirheumatic drug.

靶點：

IL Receptor;ILReceptor

體內研究：

After repeated oral administration of Esonarimod (14C-KE-298), the radioactivity decreases rapidly and no tendency towards accumulation is found

細胞實驗：

For in vitro experiment, Esonarimod (KE-298) is dissolved in ethanol and diluted with culture medium or distilled water.RAW264.7 cells are used in this study. For NO production, RAW264.7 cells [2×105/0.2 mL of RPMI-1640 supplemented by 10% heat inactivated fetal bovine serum (FBS), penicillin G (100 U/mL), and streptomycin (100 μg/mL)] are stimulated with 100 ng/mL of Escherichia coli 026:B6 lipopolysaccharide in the presence of Esonarimod (KE-298) (0, 10, 30, 100, 200, 300 μg/mL) in 96 well plates and incubated 24 h at 37°C in an atmosphere of 5% CO2 in air. After incubation, the supernatants are collected and assayed for nitrite (NO2-) instead of NO

動物實驗：

Seven-week-old male Wistar rats is administered Esonarimod (5 mg/kg once daily) orally by gastric intubation

參考文獻：

1.Inoue T, et al. KE-298 and its active metabolite KE-758 suppress nitric oxide production by murine macrophage cells and peritoneal cells from rats with adjuvant induced arthritis. J Rheumatol. 2001 Jun;28(6):1229-37. 2.Hasegawa M, et al. Formation of a disulfide protein conjugate of the SH-group-containing metabolite (M-I) ofesonarimod (KE-298) and its elimination in rats. J Pharm Pharmacol. 2002 Apr;54(4):493-8.

溶解性：

DMSO:10 mM

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.567 ml	17.836 ml	35.671 ml
5 mM	0.713 ml	3.567 ml	7.134 ml
10 mM	0.357 ml	1.784 ml	3.567 ml
50 mM	0.071 ml	0.357 ml	0.713 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

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ESONARIMOD

2-acetylthiomethyl-3-(4-methylbenzoyl)propionic acid