貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S81555-5mg	99.2%	￥440.00 S81555-5mg ￥440.00 現(xiàn)貨	9 9	-	-	-
S81555-10mg	99.2%	￥752.00 S81555-10mg ￥752.00 現(xiàn)貨	9 9	-	-	-
S81555-25mg	99.2%	￥1520.00 S81555-25mg ￥1520.00 現(xiàn)貨	6 6	-	-	-
S81555-50mg	99.2%	￥2480.00 S81555-50mg ￥2480.00 現(xiàn)貨	4 4	-	-	-

產(chǎn)品介紹

A 438079 (hydrochloride) is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9.

產(chǎn)品描述：

A 438079 (hydrochloride) is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9.

靶點(diǎn)：

pIC50: 6.9;P2XReceptor

體內(nèi)研究：

A 438079 (80 μmol/kg, i.v.) reduces noxious and innocuous evoked activity of different classes of spinal neurons in neuropathic rats. A 438079 (100 and 300 μmol/kg, i.p.) signi?cantly raises withdrawal thresh-olds in both the SNL and CCI models. Intraperitoneal injection of A 438079 (5 and 15 mg/kg) 60 min after triggering seizures reduces seizure severity and neuronal death within the hippocampus. A 438079 has superior neuroprotective effects compared with an equally dose of phenobarbital (25 mg/kg). A 438079 partially but signi?cantly prevents the 6-OHDA-induced depletion of striatal DA stores. Pretreatment with A 438079 reduces nociceptive behaviour scores in the HC model

參考文獻(xiàn)：

1. McGaraughty S, et al. P2X7-related modulation of pathological nociception in rats. Neuroscience. 2007 Jun 8;146(4):1817-28. 2. Mesuret G, et al. CNS Neurosci Ther. 2014 Jun;20(6):556-64. 3. Marcellino D, et al. On the role of P2X(7) receptors in dopamine nerve cell degeneration in a rat model of Parkinson's disease: studies with the P2X(7) receptor antagonist A-438079. J Neural Transm (Vienna). 2010 Jun;117(6):681-7. 4. Martins JP, et al. The role of P2X7 purinergic receptors in inflammatory and nociceptive changes accompanying cyclophosphamide-induced haemorrhagic cystitis in mice. Br J Pharmacol. 2012 Jan;165(1):183-96.

溶解性：

H2O : ≥ 350 mg/mL (1021.57 mM) DMSO : ≥ 100 mg/mL (291.88 mM)

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.919 ml	14.594 ml	29.188 ml
5 mM	0.584 ml	2.919 ml	5.838 ml
10 mM	0.292 ml	1.459 ml	2.919 ml
50 mM	0.058 ml	0.292 ml	0.584 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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批號(hào)：JS298415 貨號(hào)：S20001-25g
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A 438079 hydrochloride

3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine Hydrochloride