貨號	規格	價格	上海	北京	武漢	南京
S81543-5mg	99.6%	￥320.00 S81543-5mg ￥320.00 現貨	5 5	-	-	-
S81543-10mg	99.6%	￥600.00 S81543-10mg ￥600.00 現貨	5 5	-	-	-
S81543-50mg	99.6%	￥1600.00 S81543-50mg ￥1600.00 現貨	7 7	-	-	-
S81543-250mg	99.6%	￥3200.00 S81543-250mg ￥3200.00 現貨	2 2	-	-	-

產品介紹

WP1066 is an inhibitor of JAK2 and STAT3, and also shows effect on STAT5 and ERK1/2, without affecting JAK1 and JAK3.

產品描述：

WP1066 is an inhibitor of JAK2 and STAT3, and also shows effect on STAT5 and ERK1/2, without affecting JAK1 and JAK3.

靶點：

JAK2;STAT3;Apoptosis;?JAK;?STAT

體內研究：

WP1066 (30 mg/kg, o.g.) exerts an additive effect to CTX inhibition of the p-STAT3 pathway within the tumor microenvironment

參考文獻：

1. Verstovsek S, et al. WP1066, a novel JAK2 inhibitor, suppresses proliferation and induces apoptosis in erythroid human cells carrying the JAK2 V617F mutation. Clin Cancer Res, 2008, (3), 788-796. 2. Hatiboglu MA, et al. The tumor microenvironment expression of p-STAT3 influences the efficacy of WP1066 in murine melanoma models. Int J Cancer, 2012, 131(1), 8-17 3. Ferrajoli A, et al. WP1066 disrupts Janus kinase-2 and induces caspase-dependent apoptosis in acute myelogenous leukemia cells. Cancer Res, 2007, 67(23), 11291-11299.

溶解性：

DMSO : ≥ 44 mg/mL (123.52 mM) Ethanol : 16.67 mg/mL (46.80 mM; Need ultrasonic)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.807 ml	14.036 ml	28.073 ml
5 mM	0.561 ml	2.807 ml	5.615 ml
10 mM	0.281 ml	1.404 ml	2.807 ml
50 mM	0.056 ml	0.281 ml	0.561 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻(2篇)

2. [IF=7.2] Chaoyang Wang et al."Ginkgetin exhibits antifibrotic effects by inducing hepatic stellate cell apoptosis via STAT1 activation."PHYTOTHERAPY RESEARCH.2024 Jan;: 1. [IF=5.1] Jing Bei et al."(+)-Catechin Alleviates CCI-Induced Neuropathic Pain in Rats by Modulating the IL34/CSFIR Axis and Attenuating the Schwann Cell-Macrophage Cascade Response in the DRG."MOLECULAR NEUROBIOLOGY.2023 Dec;:1-15

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