貨號	規格	價格	上海	北京	武漢	南京
S81525-5mg	≥98%	￥150.00 S81525-5mg ￥150.00 現貨	5 5	-	-	-
S81525-25mg	≥98%	￥350.00 S81525-25mg ￥350.00 現貨	7 7	-	-	-
S81525-100mg	≥98%	￥500.00 S81525-100mg ￥500.00 現貨	8 0 8	-	-	-
S81525-250mg	≥98%	￥950.00 S81525-250mg ￥950.00 2-3天	0 貨期：2-3天	-	-	-
S81525-1g	≥98%	￥2580.00 S81525-1g ￥2580.00 2-3天	0 貨期：2-3天	-	-	-

產品介紹

TAS-102 is a novel oral combination drug containing trifluridine (TFT) and Tipiracil hydrochloride (TTP) in a molar ratio of 2:1.

產品描述：

TAS-102 is a novel oral combination drug containing trifluridine (TFT) and Tipiracil hydrochloride (TTP) in a molar ratio of 2:1.

靶點：

DNA/RNA Synthesis;Nucleoside Antimetabolite/Analog;NucleosideAntimetabolite/Analog;?DNA/RNASynthesis

體外研究：

TAS-102 is an oral combination drug consisting of trifluridine (FTD), which is a thymidine-based nucleoside analog, and tipiracil hydrochloride (TPI), which improves the bioavailability of FTD by inhibiting its catabolism by thymidine phosphorylase (TP). Phosphorylated form of trifluridine is incorporated into DNA resulting in DNA dysfunction and cell cycle arrest. Thymidine phosphorylase inhibitor inhibits degradation of FTD and inhibits angiogenesis. Thus, TAS-102 treatment results in massive trifluridine incorporation into DNA and in activation of similar DNA damage response pathways, which involve phosphorylation of Chk1 and cycle arrest during the G2/M-phase

體內研究：

The elimination half-life of FTD after intravenous administration to humans is very rapid (18 minutes), due to the rapid degradation of FTD to its major metabolite, 5-trifluoromethyl-2,4(1H,3H)-pyrimidinedione. In monkeys, the plasma FTD level after oral administration alone is very low, suggesting extensive first-pass metabolism by the liver and intestine TPase. However, the addition of TPI(tipiracil hydrochloride) is found to enable oral administration. By inhibiting TP, TPI inhibits the degradation of FTD in the liver and intestines following oral administration and thereby improves its bioavailability. The TP enzyme catalyzes the phosphorolysis of pyrimidine 2'-deoxynucleosides such as FTD. Studies using human CRC tumor xenografts in mice determine that the maximum antitumor activity is achieved with a 1:0.5 molar ratio, and studies in mice and monkeys show that the maximum plasma concentration of FTD is almost achieved with the same ratio. Moreover, this ratio produces a favorable balance between antitumor activity and toxicity. Lower toxicity in mice is observed with TPI coadministration than with FTD alone. TAS-102 (FTD) can overcome acquired resistance to 5-FU because the main mechanism of TAS-102 is not associated with main metabolic enzymes of 5-FU, such as TS and OPRT. TAS-102 has demonstrated efficacy in 5-FU-refractory cancers

參考文獻：

1. Nukatsuka M, et al. Efficacy of Combination Chemotherapy Using a Novel Oral Chemotherapeutic Agent, TAS-102, with Oxaliplatin on Human Colorectal and Gastric Cancer Xenografts. Anticancer Res. 2015, 35(9):4605-15. 2. Lenz HJ, et al. TAS-102, a novel antitumor agent: a review of the mechanism of action. Cancer Treat Rev. 2015, 41(9):777-83.

溶解性：

Soluble in DMSO、Ethanol

保存條件：

-20°C;充氬

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.738 ml	8.691 ml	17.382 ml
5 mM	0.348 ml	1.738 ml	3.476 ml
10 mM	0.174 ml	0.869 ml	1.738 ml
50 mM	0.035 ml	0.174 ml	0.348 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

質檢證書(COA)

輸入產品批號：

如何獲取質檢證書(COA)?

請輸入貨號和一個與之匹配的批號。
例如:
批號：JS298415 貨號：S20001-25g
在貨品標簽上如何找到貨號和批號?

摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

質量

濃度

體積

分子摩爾量

計算重置

玖玖资源网站,爆乳久久久,日韩精品乱码久久久蜜桃,精品呦国产一区二区三区,国产伦高清一区二区三区,sese一区二区,午夜精品福利一区二区三区,三级黄色网站久久免费