貨號	規(guī)格	價格	上海	北京	武漢	南京
S81518-5mg	98.5%	￥608.00 S81518-5mg ￥608.00 現貨	6 6	-	-	-
S81518-10mg	98.5%	￥1120.00 S81518-10mg ￥1120.00 現貨	4 4	-	-	-
S81518-25mg	98.5%	￥1600.00 S81518-25mg ￥1600.00 現貨	4 4	-	-	-
S81518-100mg	98.5%	￥4400.00 S81518-100mg ￥4400.00 現貨	1 1	-	-	-

產品介紹

PX-478 is an orally active HIF-1α inhibitor with potent antitumor activities. PX-478 can cross the blood-brain barrier

產品描述：

PX-478 is an orally active HIF-1α inhibitor with potent antitumor activities. PX-478 can cross the blood-brain barrier

靶點：

HIF-1α;HIF/HIFProlyl-Hydroxylase;?HIF;?Autophagy

體內研究：

PX-478 is administered to mice with congenital HO (Nfatc1-Cre/caACVR1fl/fl) every other day starting from birth for 2 wk. Treated mice have significantly less ectopic bone at the ankle joints compared with mutant mice treated with vehicle (6.8 mm3?vs. 2.2 mm3, P<0.01)

參考文獻：

1. Palayoor ST, et al. PX-478, an inhibitor of hypoxia-inducible factor-1alpha, enhances radiosensitivity of prostate carcinoma cells. Int J Cancer. 2008 Nov 15;123(10):2430-2437. 2. Agarwal S, et al. Inhibition of Hif1α prevents both trauma-induced and genetic heterotopic ossification. Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):E338-47.

溶解性：

DMSO : 100 mg/mL (253.73 mM; Need ultrasonic) H2O : ≥ 35 mg/mL (88.81 mM)

保存條件：

-20℃，氮氣保存

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.537 ml	12.686 ml	25.372 ml
5 mM	0.507 ml	2.537 ml	5.074 ml
10 mM	0.254 ml	1.269 ml	2.537 ml
50 mM	0.051 ml	0.254 ml	0.507 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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PX-478

(S)-4-(2-amino-2-carboxyethyl)-N,N-bis(2-chloroethyl)aniline oxide dihydrochloride