貨號	規格	價格	上海	北京	武漢	南京
S81500-10mg	≥99%(GC)	￥240.00 S81500-10mg ￥240.00 現貨	9 9	-	-	-
S81500-50mg	≥99%(GC)	￥480.00 S81500-50mg ￥480.00 現貨	7 7	-	-	-
S81500-250mg	≥99%(GC)	￥800.00 S81500-250mg ￥800.00 現貨	1 1	-	-	-

產品介紹

Malotilate (NKK 105), an orally active hepatotropic agent and an anti-fibrotic substance, selectively inhibits the 5-lipoxygenase (5-LOX) (IC50=4.7 μM). Malotilate prevents the development of hepatocytic injury in alcohol-pyrazole hepatitis by decreasing hepatic acetaldehyde levels and preventing the retention of transferrin in the hepatocytes

產品描述：

靶點：

5-Lipoxygenase:4.7 μM (IC50);Lipoxygenase

體內研究：

Malotilate (100 mg/kg; p.o.; daily for 3 days) treatment in rats with hypocholesterolemia results in a rapid normalization of lowered serum cholesterol

參考文獻：

1. Matsuda Y, et al. Effects of malotilate on alcoholic liver injury in rats. Alcohol Clin Exp Res. 1988;12(5):665-670. 2. Vermeer MA, Wilson JH, Zijlstra FJ, Vincent JE. Differential effects of malotilate on 5-, 12- and 15-lipoxygenase in human ascites cells. Agents Actions. 1989;26(1-2):252-253. 3. Poeschl A, et al. Malotilate reduces collagen synthesis and cell migration activity of fibroblasts in vitro. Biochem Pharmacol. 1987;36(22):3957-3963. 4. Zijlstra FJ, et al. Differential effects of malotilate on 5-, 12- and 15-lipoxygenase in human ascites cells. Eur J Pharmacol. 1989;159(3):291-295. 5. Wakasugi J, et al. Action of malotilate on reduced serum cholesterol level in rats with carbon tetrachloride-induced liver damage. Jpn J Pharmacol. 1985;38(4):391-401.

溶解性：

DMSO : ≥ 100 mg/mL (346.76 mM)

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.468 ml	17.338 ml	34.676 ml
5 mM	0.694 ml	3.468 ml	6.935 ml
10 mM	0.347 ml	1.734 ml	3.468 ml
50 mM	0.069 ml	0.347 ml	0.694 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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