貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S81495-2mg	99.2%	￥180.00 S81495-2mg ￥180.00 現(xiàn)貨	10 10	-	-	-
S81495-5mg	99.2%	￥245.00 S81495-5mg ￥245.00 現(xiàn)貨	6 6	-	-	-
S81495-10mg	99.2%	￥440.00 S81495-10mg ￥440.00 現(xiàn)貨	7 7	-	-	-
S81495-25mg	99.2%	￥840.00 S81495-25mg ￥840.00 現(xiàn)貨	7 7	-	-	-
S81495-50mg	99.2%	￥1400.00 S81495-50mg ￥1400.00 現(xiàn)貨	4 4	-	-	-
S81495-100mg	≥97%	￥1900.00 S81495-100mg ￥1900.00 2-3天	0 貨期：2-3天	-	-	-
S81495-200mg	≥97%	￥3500.00 S81495-200mg ￥3500.00 2-3天	0 貨期：2-3天	-	-	-

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產(chǎn)品介紹

Losmapimod (GSK-AHAB) is a selective, potent, and orally active p38 MAPK inhibitor with pKis of 8.1 and 7.6 for p38α and p38β, respectively

產(chǎn)品描述：

Losmapimod (GSK-AHAB) is a selective, potent, and orally active p38 MAPK inhibitor with pKis of 8.1 and 7.6 for p38α and p38β, respectively

靶點(diǎn)：

pKi: 8.1 (p38α), 7.6 (p38β);p38MAPK;?Autophagy

體內(nèi)研究：

In the spontaneously hypertensive stroke-prone rat (SHR-SP), chronic treatment with GSK-AHAB significantly and dose-dependently improves survival, endothelial-dependent and -independent vascular relaxation, and indices of renal function, and it attenuates dyslipidemia, hypertension, cardiac remodeling, plasma renin activity (PRA), aldosterone, and interleukin-1β (IL-1β)

參考文獻(xiàn)：

1. Willette RN, et al. Differential effects of p38 mitogen-activated protein kinase and cyclooxygenase 2 inhibitors in a model of cardiovascular disease. J Pharmacol Exp Ther. 2009 Sep;330(3):964-70. 2. Zhang XM, et al. Suppression of mitochondrial fission in experimental cerebral ischemia: The potential neuroprotective target of p38 MAPK inhibition. Neurochem Int. 2015 Nov;90:1-8.

溶解性：

Ethanol : 33.33 mg/mL (86.92 mM; Need ultrasonic) DMSO : 27.5 mg/mL (71.72 mM; Need ultrasonic)

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.608 ml	13.039 ml	26.078 ml
5 mM	0.522 ml	2.608 ml	5.216 ml
10 mM	0.261 ml	1.304 ml	2.608 ml
50 mM	0.052 ml	0.261 ml	0.522 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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