貨號	規(guī)格	價格	上海	北京	武漢	南京
S81436-1mg	95.1%	￥326.40 S81436-1mg ￥326.40 現(xiàn)貨	5 5	-	-	-
S81436-2mg	95.1%	￥544.00 S81436-2mg ￥544.00 現(xiàn)貨	5 5	-	-	-
S81436-5mg	95.1%	￥1020.00 S81436-5mg ￥1020.00 現(xiàn)貨	4 4	-	-	-
S81436-10mg	95.1%	￥1496.00 S81436-10mg ￥1496.00 現(xiàn)貨	5 5	-	-	-
S81436-25mg	≥95%	￥3060.00 S81436-25mg ￥3060.00 2-3天	0 貨期：2-3天	-	-	-
S81436-50mg	≥95%	￥4800.00 S81436-50mg ￥4800.00 2-3天	0 貨期：2-3天	-	-	-

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產(chǎn)品介紹

Ixabepilone (BMS-247550) is an orally bioavailable microtubule inhibitor, which binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arrests cells in the G2-M phase of the cell cycle and induces tumor cell apoptosis.

產(chǎn)品描述：

靶點：

Apoptosis;Microtubule Associated;Apoptosis;?MicrotubuleAssociated

體內(nèi)研究：

In vivo, BMS-247550 has clearly demonstrated antitumor activity that is superior to paclitaxel in both paclitaxel-resistant and -sensitive tumors. BMS-247550 is more efficacious compared to paclitaxel in all five paclitaxel-resistant tumors evaluated in this study (four human and one murine): i.e., the clinically derived paclitaxel resistant Pat-7 ovarian carcinoma, the A2780Tax ovarian carcinoma that is resistant to paclitaxel because of tubulin mutations, the HCT116/VM46 MDR colon carcinoma, the clinically derived paclitaxel-resistant Pat-21 breast carcinoma, and the murine fibrosarcoma M5076. Against three paclitaxel-sensitive human tumor xenografts, BMS-247550 produces antitumor activity equivalent to paclitaxel: i.e., A2780 human ovarian carcinoma, HCT116, and LS174T human colon carcinoma

細(xì)胞實驗：

HCT116 cells from cultures are collected by trypsinization after 1, 2, 4, 8, 16, and 24 h exposure to 7.5 nm of BMS-247550. Cells are pelleted and fixed in 80% ethanol at ?20°C. After an overnight storage at ?20°C, cells are rehydrated with PBS buffer and DNA stain by incubation with propidium iodide (5 μg/ml) in 0.1% RNase for 15–30 min. Fluorescence-activated cell sorter acquisition is performed using the FACS Calibur instrument and analysis is done using Cellquest and Modfit software. (Only for Reference)

參考文獻(xiàn)：

1.Lee FY, et al. Clin Cancer Res. 2001, 7(5):1429-1437.

溶解性：

Ethanol:93 mg/mL (183.5 mM) DMSO:93 mg/mL (183.5 mM) H2O:<1 mg/mL

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.974 ml	9.868 ml	19.736 ml
5 mM	0.395 ml	1.974 ml	3.947 ml
10 mM	0.197 ml	0.987 ml	1.974 ml
50 mM	0.039 ml	0.197 ml	0.395 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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