品牌	貨號	產(chǎn)品規(guī)格	價格(RMB)	庫存（上海）	北京	武漢	南京
源葉(MedMol)	S81435-5mg	98%	￥210.00元	9	-	-	-
源葉(MedMol)	S81435-10mg	98%	￥350.00元	9	-	-	-
源葉(MedMol)	S81435-25mg	98%	￥530.00元	7	-	-	-
源葉(MedMol)	S81435-100mg	98%	￥1680.00元	2	-	-	-
源葉(MedMol)	S81435-250mg	98%	￥2720.00元	預(yù)計交期：2-3天	-	-	-

產(chǎn)品介紹

1400W dihydrochloride is a potent and selective inhibitor of human inducible NO synthase with Ki values of 7 nM.

產(chǎn)品描述： 1400W dihydrochloride is a potent and selective inhibitor of human inducible NO synthase with Ki values of 7 nM.

靶點： Ki: 7 nM (iNOS), 2 μM (nNOS), 50 μM (eNOS);NOS;?NOSynthase

體外研究：
1400W is a slow, tight binding inhibitor of human inducible nitric- oxide synthase (iNOS). The slow onset of inhibition by 1400W shows saturation kinetics with a maximal rate constant of 0.028 s-1 and a binding constant of 2.0 μM. Inhibition is dependent on the cofactor NADPH. 1400W is at least 5000-fold selective for iNOS versus eNOS. In contrast, inhibition of human neuronal NOS and endothelial NOS (eNOS) is relatively weaker, rapidly reversible, and competitive with L-arginine, with Ki values of 2 μM and 50 μM, respectively. 1400W treatment inhibits iNOS expression without affecting nNOS or eNOS. 1400W also reduces NO, 3-NT and MDA production, and prevents neuronal cell apoptosis in cerebral cortex.

體內(nèi)研究：
1400W potently (ED50=0.3 mg/kg) reduces the delayed vascular injury in rats attributable to LPS-induced iNOS but fails to exacerbate acute vascular leakage when given concurrently with LPS. Administration of 1400W lowers NOx levels in all the experimental groups. In addition, lipid peroxidation, the percentage of apoptotic cells, and nitrated protein expression fall in the late post-hypoxia period (48 h and 5 days).

參考文獻：
1. Garvey EP, et al. 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J Biol Chem. 1997 Feb 21;272(8):4959-63. 2. Shi Q, et al. 1400W ameliorates acute hypobaric hypoxia/reoxygenation-induced cognitive deficits by suppressing the induction of inducible nitric oxide synthase in rat cerebral cortex microglia. Behav Brain Res. 2017 Feb 15;319:188-199. 3. Rus A, et al. Inducible NOS inhibitor 1400W reduces hypoxia/re-oxygenation injury in rat lung. Redox Rep. 2010;15(4):169-78.

溶解性： Soluble in DMSO、H2O

保存條件： -20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.997 ml	19.986 ml	39.973 ml
5 mM	0.799 ml	3.997 ml	7.995 ml
10 mM	0.4 ml	1.999 ml	3.997 ml
50 mM	0.08 ml	0.4 ml	0.799 ml

注意：

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參考文獻

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1400 W Dihydrochloride 98%

1400 W Dihydrochloride