貨號	規(guī)格	價格	上海	北京	武漢	南京
S81432-1mg	98.02%	￥300.00 S81432-1mg ￥300.00 現(xiàn)貨	5 5	-	-	-
S81432-5mg	≥98%	￥900.00 S81432-5mg ￥900.00 2-3天	0 貨期：2-3天	-	-	-
S81432-25mg	98.02%	￥3500.00 S81432-25mg ￥3500.00 現(xiàn)貨	1 1	-	-	-

產(chǎn)品介紹

Z-DEVD-FMK is a specific and irreversible caspase-3 inhibitor with an IC50 of 18 μM

產(chǎn)品描述：

Z-DEVD-FMK is a specific and irreversible caspase-3 inhibitor with an IC50 of 18 μM

靶點：

Caspase-3:18 μM (IC50);Caspase

體內(nèi)研究：

Early Z-DEVD-FMK (160 ng) treatment improves motor and cognitive function after traumatic CNS injury induced by severe controlled cortical impact (CCI) in the mouse. Treatment with Z-DEVD-FMK (160 ng) significantly improves neurological outcome when compared with traumatized animals treated with DMSO vehicle (p<0.01)

參考文獻：

1. Kanthasamy AG, et al. A novel peptide inhibitor targeted to caspase-3 cleavage site of a proapoptotic kinase protein kinase C delta (PKCdelta) protects against dopaminergic neuronal degeneration in Parkinson's disease models. Free Radic Biol Med. 2006 Nov 2. Knoblach SM, et al. Caspase inhibitor z-DEVD-fmk attenuates calpain and necrotic cell death in vitro and after traumatic brain injury. J Cereb Blood Flow Metab. 2004 Oct;24(10):1119-32. 3. Yakovlev AG, et al. Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury. J Neurosci. 1997, 17(19), 7415-7424. 4. Huang MY, et al. Chemotherapeutic agent CPT-11 eliminates peritoneal resident macrophages by inducing apoptosis. Apoptosis. 2016 Feb;21(2):130-42.

溶解性：

DMSO : ≥ 50 mg/mL (74.78 mM)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.496 ml	7.478 ml	14.955 ml
5 mM	0.299 ml	1.496 ml	2.991 ml
10 mM	0.15 ml	0.748 ml	1.496 ml
50 mM	0.03 ml	0.15 ml	0.299 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻

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