貨號	規(guī)格	價格	上海	北京	武漢	南京
S81415-1mg	98.12%	￥425.00 S81415-1mg ￥425.00 現(xiàn)貨	22 >10	-	-	-
S81415-5mg	98.12%	￥1190.00 S81415-5mg ￥1190.00 現(xiàn)貨	12 >10	-	-	-
S81415-10mg	98.12%	￥1900.00 S81415-10mg ￥1900.00 現(xiàn)貨	6 6	-	-	-
S81415-25mg	98.12%	￥2550.00 S81415-25mg ￥2550.00 現(xiàn)貨	7 7	-	-	-

產(chǎn)品介紹

Z-VAD(OMe)-FMK (Z-Val-Ala-Asp(OMe)-FMK) is a cell-permeable and irreversible pan-caspase inhibitor. Z-VAD(OMe)-FMK is an ubiquitin carboxy-terminal hydrolase L1 (UCHL1) inhibitor. Z-VAD(OMe)-FMK irreversibly modifies UCHL1 by targeting the active site of UCHL1

產(chǎn)品描述：

靶點：

Caspase

體內(nèi)研究：

The survival rate of mice is prolonged significantly by the injection of Z-VAD(OMe)-FMK (Z-Val-Ala-Asp(OMe)-FMK). All mice succumbed to LPS within 30 hours. By contrast, the mice treated with Z-VAD(OMe)-FMK survive significantly longer and 27% of the mice survived more than 7 days

參考文獻(xiàn)：

1. Kawasaki M, et al. Protection from lethal apoptosis in lipopolysaccharide-induced acute lung injury in mice by a caspaseinhibitor. Am J Pathol. 2000 Aug;157(2):597-603. 2. Davies CW, et al. The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK). Bioorg Med Chem Lett. 2012 Jun 15;22(12):3900-4. 3. Park S, et al. Neurovascular protection reduces early brain injury after subarachnoid hemorrhage. Stroke. 2004 Oct;35(10):2412-7. 4. Ilangovan R, et al. Inhibition of apoptosis by Z-VAD-fmk in SMN-depleted S2 cells. J Biol Chem. 2003 Aug 15;278(33):30993-9.

溶解性：

DMSO : 100 mg/mL (213.91 mM; Need ultrasonic)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.139 ml	10.695 ml	21.391 ml
5 mM	0.428 ml	2.139 ml	4.278 ml
10 mM	0.214 ml	1.07 ml	2.139 ml
50 mM	0.043 ml	0.214 ml	0.428 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)(7篇)

7. [IF=4.6] Miaomiao Zhang et al."Unlocking the Potential of Perillaldehyde: A Novel Mechanism for Chronic Myeloid Leukemia by Targeting HSP70."MOLECULES.2025 May;30(11):2294 6. [IF=5.5] Ling Wang et al."Thioredoxin reductase inhibition and glutathione depletion mediated by glaucocalyxin A promote intracellular disulfide stress in gastric cancer cells."FEBS Journal.2024 Oct;: 5. [IF=4.8] Sheng-long Gu et al."Eupalinolide B alleviates rheumatoid arthritis through the promotion of apoptosis and autophagy via regulating the AMPK/mTOR/ULK-1 signaling axis."INTERNATIONAL IMMUNOPHARMACOLOGY.2025 Feb;148:114179 4. [IF=14] Jiahao Liang et al."Shikonin and chitosan-silver nanoparticles synergize against triple-negative breast cancer through RIPK3-triggered necroptotic immunogenic cell death."BIOMATERIALS".2024 May;:122608 3. [IF=9.7] Xiaokang Zhu et al."A multi-mode Rhein-based nano-platform synergizing ferrotherapy/chemotherapy-induced immunotherapy for enhanced tumor therapy."Acta Biomaterialia".2024 Apr;:

2. [IF=7.9] Tianyu Meng et al."Rubusoside mitigates neuroinflammation and cellular apoptosis in Parkinson's disease, and alters gut microbiota and metabolite composition."PHYTOMEDICINE.2023 Dec;:155309 1. [IF=4.6] Minghui Liu et al."Benzophenanthridine Alkaloid Chelerythrine Elicits Necroptosis of Gastric Cancer Cells via Selective Conjugation at the Redox Hyperreactive C-Terminal Sec498 Residue of Cytosolic Selenoprotein Thioredoxin Reductase."MOLECULES.10.3390/mol

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Z-VAD-FMK