貨號	規(guī)格	價格	上海	北京	武漢	南京
S81398-5mg	98.2%	￥365.00 S81398-5mg ￥365.00 現(xiàn)貨	6 6	-	-	-
S81398-10mg	98.2%	￥600.00 S81398-10mg ￥600.00 現(xiàn)貨	7 7	-	-	-
S81398-25mg	98.2%	￥1210.00 S81398-25mg ￥1210.00 現(xiàn)貨	6 6	-	-	-
S81398-100mg	≥97%	￥3200.00 S81398-100mg ￥3200.00 2-3天	0 貨期：2-3天	-	-	-

產(chǎn)品介紹

Y-33075 dihydrochloride is a selective ROCK inhibitor with an IC50 of 3.6 nM.

產(chǎn)品描述：

Y-33075 dihydrochloride is a selective ROCK inhibitor with an IC50 of 3.6 nM.

靶點：

ROCK:3.6 nM (IC50);PKC:420 nM (IC50);CaMKII:810 nM (IC50)

體內(nèi)研究：

In rabbits, Y-39983 (≥0.01%) significantly lowers intraocular pressure (IOP) at 2 hours after topical administration. In monkeys, Y-39983 (0.05%)-treated eyes show significant reduction of IOP between 2 and 7 hours after topical administration. Y-39983 (100 μM) increases the regenerating axons of retinal ganglion cells (RGCs) in the eyes of the rats

參考文獻(xiàn)：

1. Hideki Tokushige, et al. Effects of Topical Administration of Y-39983, a Selective Rho-Associated Protein Kinase Inhibitor, on Ocular Tissues in Rabbits and Monkeys Invest. Ophthalmol. Vis. Sci. July 2007 vol. 48no. 7 3216-3222 2. Tokushige H, et al. Effects of Y-39983, a selective Rho-associated protein kinase inhibitor, on blood flow in optic nerve head in rabbits and axonal regeneration of retinal ganglion cells in rats. Curr Eye Res. 2011 Oct;36(10):964-70. 3. Watabe H, et al. Effects of Rho-associated protein kinase inhibitors Y-27632 and Y-39983 on isolated rabbit ciliary arteries.Jpn J Ophthalmol. 2011 Jul;55(4):411-7. Epub 2011 Jun 11.

溶解性：

DMSO : 100 mg/mL (283.09 mM; Need ultrasonic) H2O : 50 mg/mL (141.54 mM; Need ultrasonic)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.831 ml	14.154 ml	28.309 ml
5 mM	0.566 ml	2.831 ml	5.662 ml
10 mM	0.283 ml	1.415 ml	2.831 ml
50 mM	0.057 ml	0.283 ml	0.566 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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Y-39983 HCl