貨號	規(guī)格	價格	上海	北京	武漢	南京
S81389-2mg	99.8%	￥120.00 S81389-2mg ￥120.00 現(xiàn)貨	5 5	-	-	-
S81389-5mg	99.8%	￥240.00 S81389-5mg ￥240.00 現(xiàn)貨	6 6	-	-	-
S81389-10mg	99.8%	￥390.00 S81389-10mg ￥390.00 現(xiàn)貨	5 5	-	-	-
S81389-25mg	99.8%	￥800.00 S81389-25mg ￥800.00 現(xiàn)貨	6 6	-	-	-
S81389-50mg	≥98%	￥1350.00 S81389-50mg ￥1350.00 2-3天	0 貨期：2-3天	-	-	-
S81389-100mg	≥98%	￥2000.00 S81389-100mg ￥2000.00 2-3天	0 貨期：2-3天	-	-	-

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產(chǎn)品介紹

SGC707 is a potent, selective, and non-competitive PRMT3 (protein arginine methyltransferase 3) inhibitor (IC50=31 nM, Kd=53 nM).

產(chǎn)品描述：

SGC707 is a potent, selective, and non-competitive PRMT3 (protein arginine methyltransferase 3) inhibitor (IC50=31 nM, Kd=53 nM).

靶點：

PRMT3:31 nM (IC50);HistoneMethyltransferase

體外研究：

SGC707 (0-10 μM; 6 h) binds to PRMT3 in both HEK293 and A549 cells. Cell Viability Assay Cell Line: HEK293 and A549 cells Concentration: 0-10 μM Incubation Time: 6 hours Result: Stabilized PRMT3 in both HEK293 and A549 cells with EC50 values of 1.3 μM and 1.6 μM, respectively.

體內(nèi)研究：

SGC707 (intraperitoneal injection; 10 mg/kg; 3 times per week; 3 w) treatment reduces hepatic steatosis and plasma triglyceride levels and induces pruritus in Western-type diet-fed LDL receptor knockout mice. Animal Model: Western-type diet-fed LDL (lipoprotein) receptor knockout mice Dosage: 10 mg/kg Administration: Intraperitoneal injection; 10 mg/kg; 3 times per week; 3 weeks Result: Exhibited 50% lower liver triglyceride stores as well as 32% lower plasma triglyceride levels.

參考文獻：

1. Kaniskan Hü, et al. A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). Angew Chem Int Ed Engl. 2015 Apr 20;54(17):5166-70. 2. de Jong LM, et al. PRMT3 inhibitor SGC707 reduces triglyceride levels and induces pruritus in Western-type diet-fed LDL receptor knockout mice. Sci Rep. 2022 Jan 10;12(1):483.

溶解性：

soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.352 ml	16.759 ml	33.519 ml
5 mM	0.67 ml	3.352 ml	6.704 ml
10 mM	0.335 ml	1.676 ml	3.352 ml
50 mM	0.067 ml	0.335 ml	0.67 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻

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