貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S81379-5mg	99.9%	￥384.00 S81379-5mg ￥384.00 現(xiàn)貨	10 10	-	-	-
S81379-10mg	99.9%	￥512.00 S81379-10mg ￥512.00 現(xiàn)貨	8 8	-	-	-
S81379-25mg	99.9%	￥800.00 S81379-25mg ￥800.00 現(xiàn)貨	11 >10	-	-	-
S81379-200mg	≥99%	￥4800.00 S81379-200mg ￥4800.00 2-3天	0 貨期：2-3天	-	-	-

產(chǎn)品介紹

Remodelin, a specific inhibitor of N-acetyltransferase NAT10, can ameliorate Hutchinson-Gilford Progeria Syndrom (HGPS) cellular phenotypes. Remodelin acts in a progerin- and FTI-independent pathway, by targeting and inhibiting NAT10. NAT10 is a protein with histone acetylation activity and primarily identified to be involved in regulation of telomerase activity

產(chǎn)品描述：

靶點(diǎn)：

Histone Acetyltransferase;RAAS;?HistoneAcetyltransferase

體外研究：

Remodelin blocks invasion and migration of HCC cells in hypoxic conditions

體內(nèi)研究：

Remodelin (100?mg/kg; p.o) significantly reduces the loss of subcutaneous adipose tissue that is seen in the HGPS mouse model. Animal Model: LmnaG609G/G609G mice (HGPS mice) Dosage: 100?mg/kg Administration: P.o; daily schedule from 3 weeks of age onward, until the end-point (individual weight maxima) Result: Well-tolerated by both genotypes, with no weight loss.

參考文獻(xiàn)：

1. Balmus G, et al. Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome. Nat Commun. 2018;9(1):1700. Published 2018 Apr 27. 2. Liu H, et al. DNA damage induces N-acetyltransferase NAT10 gene expression through transcriptional activation. Mol Cell Biochem. 2007;300(1-2):249-258. 3. Ma R, et al. Up regulation of NAT10 promotes metastasis of hepatocellular carcinoma cells through epithelial-to-mesenchymal transition. Am J Transl Res. 2016;8(10):4215-4223. Published 2016 Oct 15.

溶解性：

soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.753 ml	13.764 ml	27.527 ml
5 mM	0.551 ml	2.753 ml	5.505 ml
10 mM	0.275 ml	1.376 ml	2.753 ml
50 mM	0.055 ml	0.275 ml	0.551 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

質(zhì)檢證書(COA)

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批號(hào)：JS298415 貨號(hào)：S20001-25g
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Remodelin (hydrobromide)