貨號	規格	價格	上海	北京	武漢	南京
S81370-5mg	99.1%	￥666.40 S81370-5mg ￥666.40 現貨	8 8	-	-	-
S81370-10mg	99.1%	￥884.00 S81370-10mg ￥884.00 現貨	6 6	-	-	-
S81370-50mg	99.1%	￥3060.00 S81370-50mg ￥3060.00 現貨	1 1	-	-	-

產品介紹

SGC-CBP30 is a potent and highly selective CBP/p300 bromodomain (Kds of 21 nM and 32 nM for CBP and p300, respectively) inhibitor, displaying 40-fold selectivity over the first bromodomain of BRD4 [BRD4(1)] bound. SGC-CBP30 strongly reduces secretion of IL-17A in Th17 cells and has anti-inflammatory effects

產品描述：

靶點：

CBP/p300 bromodomain;EpigeneticReaderDomain;?HistoneAcetyltransferase

體內研究：

SGC-CBP30 treatment slightly alleviates alveolar bronchial fibrosis induced by NSC-125066. SGC-CBP30 plus CQ-061 dramatically reduces alveolar bronchial fibrosis. The ELISA of cytokines IL-4 and IFN-γ in BALF demonstrates that combination of SGC-CBP300 and CQ-061 suppresses the activation of IL-4 as well as IFN-γ in NSC-125066 induced IPF murine models to nearly normal levels

參考文獻：

1. Hammitzsch A, et al. CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses. Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):10768-73. 2. Tao J, Inhibition of EP300 and DDR1 synergistically alleviates pulmonary fibrosis in vitro and in vivo. Biomed Pharmacother. 2018 Oct;106:1727-1733. 3. Hay DA, et al. Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains. J Am Chem Soc. 2014 Jul 2;136(26):9308-19.

溶解性：

DMSO : ≥ 31 mg/mL (60.90 mM)

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.964 ml	9.822 ml	19.645 ml
5 mM	0.393 ml	1.964 ml	3.929 ml
10 mM	0.196 ml	0.982 ml	1.964 ml
50 mM	0.039 ml	0.196 ml	0.393 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻(1篇)

1. [IF=4.6] Xuan Zhang et al."Activated PRDM1-CREBBP contributes to preeclampsia by regulating apoptosis and invasion of the human trophoblast cells."iScience.2024 Dec;27:

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