貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京	購買數(shù)量
S81354-5mg	≥98%	￥211.00 S81354-5mg ￥211.00 2-3天	0 貨期：2-3天	-	-	-
S81354-25mg	≥98%	￥647.00 S81354-25mg ￥647.00 2-3天	0 貨期：2-3天	-	-	-

產(chǎn)品介紹

MS 049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC 50 of 34 nM and 43 nM, respectively.

產(chǎn)品描述：

MS 049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC 50 of 34 nM and 43 nM, respectively.

靶點(diǎn)：

Histone Methyltransferase;HistoneMethyltransferase

體外研究：

In cellular assays, MS049 potently inhibits the methyltransferase activity of PRMT4 and PRMT6 and reduces levels of Med12me2a and H3R2me2a in HEK293 cells. MS049 does not inhibit any of the methyltransferases at 50 μM or demethylases at 10 μM and does not display appreciable binding to any of the methyllysine/methylarginine reader proteins using the DSF assay at 200 μM.

細(xì)胞實(shí)驗(yàn)：

HEK293 cells grown in DMEM supplemented with 10% FBS, penicillin (100 U/mL), and streptomycin (100 μg/mL) were seeded on 96-well plates at density 3000/well and treated with compounds at 0, 1, 10, and 50 μM concentrations for 96 h. The confluency was measured using IncuCyte ZOOM live cell imaging device and analyzed with IncuCyte ZOOM software based on phase contrast images.

參考文獻(xiàn)：

1. Shen Y,etal.Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6.J Med Chem. 2016 Oct 13;59(19):9124-9139.

溶解性：

soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	4.026 ml	20.132 ml	40.264 ml
5 mM	0.805 ml	4.026 ml	8.053 ml
10 mM	0.403 ml	2.013 ml	4.026 ml
50 mM	0.081 ml	0.403 ml	0.805 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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