| 貨號 | 規格 | 價格 | 上海 | 北京 | 武漢 | 南京 | 購買數量 |
|---|---|---|---|---|---|---|---|
| S81336-1mg | 98% | ￥160.00 | 10 | - | - | - |
|
| S81336-2mg | 98% | ￥300.00 | 10 | - | - | - |
|
| S81336-5mg | 98% | ￥490.00 | 6 | - | - | - |
|
| S81336-10mg | 98% | ￥600.00 | 6 | - | - | - |
|
| S81336-25mg | 98% | ￥1000.00 | 5 | - | - | - |
|
| S81336-50mg | 98% | ￥1700.00 | 貨期：2-3天 | - | - | - |
|
| S81336-100mg | 98% | ￥2700.00 | 貨期：2-3天 | - | - | - |
|
BRD73954 is a potent HDAC inhibitor and selectively inhibiting both HDAC6 and HDAC8 with IC50 values of 0.0036, 0.12, 9, 12, 23 μM for HDAC6, HDAC8, HDAC2, HDAC1 and HDAC3, respectively. BRD73954 decreases the levels of HDAC6, associated with upregulation of Ac-Tubulin
| 產品描述： | BRD73954 is a potent HDAC inhibitor and selectively inhibiting both HDAC6 and HDAC8 with IC50 values of 0.0036, 0.12, 9, 12, 23 μM for HDAC6, HDAC8, HDAC2, HDAC1 and HDAC3, respectively. BRD73954 decreases the levels of HDAC6, associated with upregulation of Ac-Tubulin | ||||||||||||||||||||
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| 靶點： | HDAC6:0.036 μM (IC50);HDAC8:0.12 μM (IC50);HDAC2:9 μM (IC50);HDAC | ||||||||||||||||||||
| 體外研究： | BRD73954 (10 μM; 48 h; HeLa cells) inhibits HDAC6 activity via upregulation of Ac-Tubulin. Western Blot Analysis Cell Line: HeLa cells Concentration: 10 μM Incubation Time: 48 hours Result: Increased inα-tubulin acetylation, no change in the acetylation state of H3 was observed. | ||||||||||||||||||||
| 參考文獻： | 1. Olson DE, et, al. Discovery of the first histone deacetylase 6/8 dual inhibitors. J Med Chem. 2013 Jun 13;56(11):4816-20. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存條件： | -20℃ | ||||||||||||||||||||
| 配置溶液濃度參考： |
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| 注意： | 部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
上海工商
滬公網安備 31011702002021號
危險品化學品經營許可證（不帶存儲）
營業執照(三證合一)
北京