品牌：源葉(MedMol)

產品編號：S81322 一鍵復制產品信息

CAS號：1421373-98-9

分子式：C₂₇H₃₁N₇O₂

分子量：485.5807

別名：N-[2-[[2-(二甲基氨基)乙基]甲基氨基]-5-[[4-(1H-吲哚-3-基)-2-嘧啶基]氨基]-4-甲氧基苯基]-2-丙烯酰胺; N-(5-((4-(1H-吲哚-3-基)嘧啶-2-基)氨基)-2-((2-(二甲氨基)乙基)(甲基)氨基)-4-甲氧苯基)丙烯酰基酰胺;;AZ 5104; N-(5-((4-(1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-

貨號	規格	價格	上海	北京	武漢	南京
S81322-2mg	99.1%	￥200.00 S81322-2mg ￥200.00 現貨	5 5	-	-	-
S81322-5mg	99.1%	￥280.00 S81322-5mg ￥280.00 現貨	6 6	-	-	-
S81322-10mg	99.1%	￥450.00 S81322-10mg ￥450.00 現貨	6 6	-	-	-
S81322-25mg	99.1%	￥815.00 S81322-25mg ￥815.00 現貨	6 6	-	-	-
S81322-50mg	≥99%	￥1440.00 S81322-50mg ￥1440.00 2-3天	0 貨期：2-3天	-	-	-
S81322-100mg	≥99%	￥2300.00 S81322-100mg ￥2300.00 2-3天	0 貨期：2-3天	-	-	-
S81322-200mg	≥99%	￥3700.00 S81322-200mg ￥3700.00 2-3天	0 貨期：2-3天	-	-	-

大包裝詢價收藏產品

加入購物車

產品介紹

AZ-5104 is an active, demethylated metabolite of AZD 9291. AZ-5104 is an?EGFR?inhibitor with?IC50s of 1, 6, 1, 25 and 7 nM for?EGFRL858R/T790M,?EGFRL858R,?EGFRL861Q,?EGFR?and ErbB4, respectively.

產品描述：

AZ-5104 is an active, demethylated metabolite of AZD 9291. AZ-5104 is an?EGFR?inhibitor with?IC50s of 1, 6, 1, 25 and 7 nM for?EGFRL858R/T790M,?EGFRL858R,?EGFRL861Q,?EGFR?and ErbB4, respectively.

靶點：

EGFRL858R/T790M:1 nM (IC50);EGFRL858R:1 nM (IC50);EGFRL861Q:6 nM (IC50);EGFR:25 nM (IC50);ErbB4:7 nM (IC50);EGFRExon 19 deletion/T790M;EGFR

體外研究：

AZ-5104 inhibits EGFR phosphorylation with IC50s of 2, 1, 2, 53, and 33 nM in H1975 (EGFRL858R/T790M), PC-9VanR (EGFRExon 19 deletion/T790M), PC-9 (EGFRExon 19 deletion), H2073 (WT), and LOVO (WT), respectively. AZ5104 exhibits a reduced selectivity margin against wild-type EGFR when compared to AZD9291. AZ5104 display minimal off-target activity against other non-HER family kinases, but has the potential to target both HER2 and HER4 kinase activity

體內研究：

The metabolite, AZ5104 (5 mg/kg/day), is effective in shrinking tumors in both C/L858R and C/L+T mice

參考文獻：

1. Cross DA, et al. AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer. Cancer Discov. 2014 Sep;4(9):1046-61.

溶解性：

soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.059 ml	10.297 ml	20.594 ml
5 mM	0.412 ml	2.059 ml	4.119 ml
10 mM	0.206 ml	1.03 ml	2.059 ml
50 mM	0.041 ml	0.206 ml	0.412 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

質檢證書(COA)

輸入產品批號：

如何獲取質檢證書(COA)?

請輸入貨號和一個與之匹配的批號。
例如:
批號：JS298415 貨號：S20001-25g
在貨品標簽上如何找到貨號和批號?

摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

質量

濃度

體積

分子摩爾量

計算重置

玖玖资源网站,爆乳久久久,日韩精品乱码久久久蜜桃,精品呦国产一区二区三区,国产伦高清一区二区三区,sese一区二区,午夜精品福利一区二区三区,三级黄色网站久久免费