貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S81320-1mg	99.8%	￥184.00 S81320-1mg ￥184.00 現(xiàn)貨	9005 >10	-	-	-
S81320-2mg	99.8%	￥280.00 S81320-2mg ￥280.00 現(xiàn)貨	4505 >10	-	-	-
S81320-5mg	99.8%	￥395.00 S81320-5mg ￥395.00 現(xiàn)貨	1805 >10	-	-	-
S81320-10mg	99.8%	￥650.00 S81320-10mg ￥650.00 現(xiàn)貨	903 >10	-	-	-
S81320-50mg	99.8%	￥1980.00 S81320-50mg ￥1980.00 現(xiàn)貨	186 >10	-	-	-
S81320-100mg	99.8%	￥3100.00 S81320-100mg ￥3100.00 現(xiàn)貨	96 >10	-	-	-

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產(chǎn)品介紹

Acalabrutinib (ACP-196) is an orally active, irreversible, and highly selective second-generation BTK inhibitor. Acalabrutinib binds covalently to Cys481 in the ATP-binding pocket of BTK. Acalabrutinib demonstrates potent on-target effects and efficacy in mouse models of chronic lymphocytic leukemia (CLL)[1]

產(chǎn)品描述：

靶點(diǎn)：

IC50: 3 nM (BTK in CD69 B cell);BTK

體內(nèi)研究：

Acalabrutinib (100 mg twice per day) assessed for thrombus formation at injured arterioles of the mice, exhibits more selective for inhibiting BTK and has virtually no inhibition of platelet activity

參考文獻(xiàn)：

1. Wu J, et al. Acalabrutinib (ACP-196): a selective second-generation BTK inhibitor. J Hematol Oncol. 2016 Mar 9;9:21 2. Herman SE, et al. The Bruton's tyrosine kinase (BTK) inhibitor acalabrutinib demonstrates potent on-target effects and efficacy in two mouse models of chronic lymphocytic leukemia. Clin Cancer Res. 2016 Nov 30

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.148 ml	10.741 ml	21.482 ml
5 mM	0.43 ml	2.148 ml	4.296 ml
10 mM	0.215 ml	1.074 ml	2.148 ml
50 mM	0.043 ml	0.215 ml	0.43 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶(hù)參考交流研究之用。

參考文獻(xiàn)

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Acalabrutinib(ACP-196)