貨號	規(guī)格	價格	上海	北京	武漢	南京	購買數(shù)量
S81239-5mg	99.7%	￥380.00 S81239-5mg ￥380.00 現(xiàn)貨	2 2	-	-	-
S81239-25mg	≥99%	￥1300.00 S81239-25mg ￥1300.00 2-3天	0 貨期：2-3天	-	-	-

產(chǎn)品介紹

Salvianolic acid B is an active ingredient of Salvia miltiorrhiza, which has been widely applied in China for the management of various microcirculation-related disorders, such as cardiovascular disease, cerebrovascular disease, and diabetic vascular complication.

產(chǎn)品描述：

靶點：

Autophagy;Sirtuin;?Autophagy

體內(nèi)研究：

Salvianolic acid B (SalB) (5 mg · kg-1 · h-1) significantly attenuates LPS-induced pulmonary microcirculatory disturbance, including the increase in leukocyte adhesion and albumin leakage. In addition, LPS increases pulmonary tissue wet-to-dry weight ratio and tumor necrosis factor [alpha] and interleukin 8 levels in plasma and bronchoalveolar lavage fluid enhances the expression of E-selectin, intercellular adhesion molecule 1, myeloperoxidase, MMP-2, and MMP-9, whereas it decreases the expression of AQP-1 and AQP-5 in pulmonary tissue, all of which are attenuated by SalB pretreatment[1]. SalB administration (10 mg/kg) significantly ameliorate the Aβ25-35 peptide-induced memory impairment in the passive avoidance task (P<0.05). SalB treatment also reduced the number of activated microglia and astrocytes that are observed during the inflammatory reaction after the administration of the Aβ25-35 peptide. Moreover, SalB markedly reduce inducible nitric oxide synthase and cyclooxygenase-2 expression levels and thiobarbituric acid reactive substances, which are increased by the administration of the Aβ25-35 peptide. Furthermore, SalB administration significantly rescue the Aβ25-35 peptide-induced decrease of choline acetyltransferase and brain-derived neurotrophic factor protein levels

參考文獻：

1. Lee YW, et al.Neuroprotective effects of salvianolic acid B on an Aβ25-35 peptide-induced mouse model of Alzheimer's disease. Eur J Pharmacol. 2013 Mar 15;704(1-3):70-7. 2. Liu P, et al. Effect of salvianolic acid B on collagen production and mitogen-activated protein kinase activity in rat hepatic stellate cells. Acta Pharmacol Sin. 2002 Aug;23(8):733-8. 3. Lin, Fang, et al. Salvianolic acid B protects from pulmonary microcirculation disturbance induced by lipopolysaccharide in rat. Shock. 2013 Mar;39(3):317-25. 4. Man Xu, et al. Analysis on the Stability of Total Phenolic Acids and Salvianolic Acid B from Salvia miltiorrhiza by HPLC and HPLC-MSn. Natural Product Communications. 2008 Vol. 3, No. 5, 669-676.

溶解性：

H2O : 50 mg/mL (69.58 mM; ultrasonic and adjust pH to 3 with HCl) DMSO : 25 mg/mL (34.79 mM; Need ultrasonic)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.392 ml	6.958 ml	13.916 ml
5 mM	0.278 ml	1.392 ml	2.783 ml
10 mM	0.139 ml	0.696 ml	1.392 ml
50 mM	0.028 ml	0.139 ml	0.278 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(1篇)

1. [IF=3.935] Zhengchao Ji et al."Global identification and quantitative analysis of representative components of Xin-Nao-Kang Capsule, a traditional Chinese medicinal formula, by UHPLC-Q-TOF-MS and UHPLC-TQ-MS."J Pharmaceut Biomed. 2021 May;198:114002

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lithospermic acid B