貨號	規格	價格	上海	北京	武漢	南京
S81231-2mg	98.3%	￥50.00 S81231-2mg ￥50.00 現貨	5 5	-	-	-
S81231-5mg	98.3%	￥60.00 S81231-5mg ￥60.00 現貨	6 6	-	-	-
S81231-10mg	98.3%	￥110.00 S81231-10mg ￥110.00 現貨	6 6	-	-	-
S81231-50mg	98.3%	￥500.00 S81231-50mg ￥500.00 現貨	3 3	-	-	-

產品介紹

CNX-774 is an orally active, irreversible and selective BTK inhibitor, with an IC50 of < 1 nM. CNX-774 specifically targets Cysteine 481 of Btk for covalent modification

產品描述：

CNX-774 is an orally active, irreversible and selective BTK inhibitor, with an IC50 of < 1 nM. CNX-774 specifically targets Cysteine 481 of Btk for covalent modification

靶點：

IC50: 1 nM (BTK);BTK

體內研究：

CNX-774 is stable and non-reactive in fresh human and rat whole blood and does not covalently bond to any of the mid-level abundance human plasma proteins. CNX-774 demonstrates potent inhibitory activity towards the intended target, Btk, while achieving remarkable specificity in a variety of assays designed to assess off-target reactivity towards abundant cellular thiols and blood proteins

參考文獻：

1. Matthew Labenski, et al. In Vitro Reactivity Assessment of Covalent Drugs Targeting Bruton's Tyrosine Kinase. 2. Akintunde Akinleye, et al. Ibrutinib and novel BTK inhibitors in clinical development. J Hematol Oncol. 2013 Aug 19;6:59.

溶解性：

DMSO : ≥ 45 mg/mL (90.09 mM)

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.002 ml	10.01 ml	20.02 ml
5 mM	0.4 ml	2.002 ml	4.004 ml
10 mM	0.2 ml	1.001 ml	2.002 ml
50 mM	0.04 ml	0.2 ml	0.4 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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