貨號	規格	價格	上海	北京	武漢	南京
S81225-5mg	98.1%	￥120.00 S81225-5mg ￥120.00 現貨	12 >10	-	-	-
S81225-10mg	98.1%	￥200.00 S81225-10mg ￥200.00 現貨	7 7	-	-	-
S81225-50mg	98.1%	￥650.00 S81225-50mg ￥650.00 現貨	11 >10	-	-	-
S81225-100mg	98.1%	￥1250.00 S81225-100mg ￥1250.00 現貨	5 5	-	-	-
S81225-400mg	98.1%	￥3200.00 S81225-400mg ￥3200.00 現貨	1 1	-	-	-

產品介紹

U0126 (U0126-EtOH) is a potent, non-ATP competitive and selective MEK1 and MEK2 inhibitor, with IC50s of 72 nM and 58 nM, respectively. U0126 is an autophagy and mitophagy inhibitor

產品描述：

U0126 (U0126-EtOH) is a potent, non-ATP competitive and selective MEK1 and MEK2 inhibitor, with IC50s of 72 nM and 58 nM, respectively. U0126 is an autophagy and mitophagy inhibitor

靶點：

MEK2:60 nM (IC50);MEK1:70 nM (IC50);Mitophagy;?InfluenzaVirus;?MEK;?Autophagy

體內研究：

Mice are treated daily with U0126-EtOH (U0126; i.p., 10.5 mg/kg). In control experiment, tumor sizes are constant or slightly increase all over the kinetic. At the opposite, in all U0126-EtOH experiments, engraftment and early tumor growth are significantly decreased. Furthermore, a 60-70% reduction in the volume of tumors treated with U0126-EtOH is obtained 9 days after injection and thereafter. Rats are subjected to 120 minutes transient middle cerebral artery occlusion (tMCAO) and thereafter treated with the U0126-EtOH (U0126; i.p., 30 mg/kg) at 0 and 24 hours of reperfusion. After treatment with U0126-EtOH, the vasoconstriction to S6c is markedly reduced

參考文獻：

1. Favata MF, et al. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem. 1998 Jul 17;273(29):18623-32. 2. Droebner K, et al. Antiviral activity of the MEK-inhibitor U0126 against pandemic H1N1v and highly pathogenic avian influenza virus in vitro and in vivo. Antiviral Res. 2011, 92(2), 195-203. 3. Bessard A, et al. RNAi-mediated ERK2 knockdown inhibits growth of tumor cells in vitro and in vivo. Oncogene. 2008 Sep 11;27(40):5315-25. 4. Ahnstedt H, et al. U0126 attenuates cerebral vasoconstriction and improves long-term neurologic outcome after stroke in female rats. J Cereb Blood Flow Metab. 2015 Mar;35(3):454-60.

溶解性：

DMSO : 50 mg/mL (117.22 mM; Need ultrasonic)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.344 ml	11.722 ml	23.443 ml
5 mM	0.469 ml	2.344 ml	4.689 ml
10 mM	0.234 ml	1.172 ml	2.344 ml
50 mM	0.047 ml	0.234 ml	0.469 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻(1篇)

1. [IF=7] Ye Jianfeng et al."TRAF7-targeted HOXA5 acts as a tumor suppressor in prostate cancer progression and stemness via transcriptionally activating SPRY2 and regulating MEK/ERK signaling."Cell Death Discovery.2023 Oct;9(1):1-15

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