貨號	規(guī)格	價格	上海	北京	武漢	南京
S81204-5mg	95.1%	￥867.00 S81204-5mg ￥867.00 現(xiàn)貨	6 6	-	-	-
S81204-10mg	95.1%	￥1368.50 S81204-10mg ￥1368.50 現(xiàn)貨	8 8	-	-	-
S81204-25mg	95.1%	￥2465.00 S81204-25mg ￥2465.00 現(xiàn)貨	5 5	-	-	-

產(chǎn)品介紹

GSK-923295 is a special, allosteric inhibitor of centromere-associated protein-E (CENP-E) kinesin motor ATPase activity, with Ki of 3.2±0.2 nM and 1.6± 0.1 nM for human and canine, respectively.

產(chǎn)品描述：

GSK-923295 is a special, allosteric inhibitor of centromere-associated protein-E (CENP-E) kinesin motor ATPase activity, with Ki of 3.2±0.2 nM and 1.6± 0.1 nM for human and canine, respectively.

靶點(diǎn)：

CENP-E:1.6 nM (Ki, Canine CENP-E);Apoptosis;?Kinesin

體內(nèi)研究：

Xenografts of mice treated with GSK-923295 (GSK923295) shows significant tumor growth delay compared to the control arm (NB-EBc1 p<0.0001; NB-1643 p=0.018; NB-1691 p=0.0018)

參考文獻(xiàn)：

1. Wood KW, et al. Antitumor activity of an allosteric inhibitor of centromere-associated protein-E. Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5839-44. 2. Mayes PA, et al. Mitogen-activated protein kinase (MEK/ERK) inhibition sensitizes cancer cells to centromere-associated protein E (CENP-E) inhibition. Int J Cancer. 2013 Feb 1;132(3):E149-57. 3. Balamuth NJ, et al. Serial transcriptome analysis and cross-species integration identifies centromere-associated protein E as a novel neuroblastoma target. Cancer Res. 2010 Apr 1;70(7):2749-58.

溶解性：

DMSO : 30 mg/mL (50.66 mM; Need ultrasonic)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.689 ml	8.444 ml	16.888 ml
5 mM	0.338 ml	1.689 ml	3.378 ml
10 mM	0.169 ml	0.844 ml	1.689 ml
50 mM	0.034 ml	0.169 ml	0.338 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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