貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S81198-5mg	99.2%	￥744.00 S81198-5mg ￥744.00 現(xiàn)貨	7 7	-	-	-
S81198-10mg	99.2%	￥1040.00 S81198-10mg ￥1040.00 現(xiàn)貨	6 6	-	-	-
S81198-25mg	99.2%	￥2240.00 S81198-25mg ￥2240.00 現(xiàn)貨	4 4	-	-	-

產(chǎn)品介紹

Xevinapant (AT-406) is a potent and orally bioavailable Smac mimetic and an antagonist of IAPs, and it binds to XIAP, cIAP1, and cIAP2 proteins with Ki of 66.4, 1.9, and 5.1 nM, respectively.

產(chǎn)品描述：

Xevinapant (AT-406) is a potent and orally bioavailable Smac mimetic and an antagonist of IAPs, and it binds to XIAP, cIAP1, and cIAP2 proteins with Ki of 66.4, 1.9, and 5.1 nM, respectively.

靶點(diǎn)：

cIAP1:1.9 nM (Ki);cIAP2:5.1 nM (Ki);XIAP:66.4 nM (Ki);IAP

體內(nèi)研究：

Xevinapant (AT-406) is very effective in inhibition of tumor growth in the MDA-MB-231 xenograft model, and has minimal toxicity to animals.Xevinapant is evaluated for its pharmacokinetic (PK) properties in mice, rats, non-human primates and dogs.

參考文獻(xiàn)：

1. Cai Q, Sun H, Peng Y, et al. A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment. J Med Chem. 2011;54(8):2714-2726.

溶解性：

DMSO : 100 mg/mL (178.03 mM; Need ultrasonic)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.78 ml	8.901 ml	17.803 ml
5 mM	0.356 ml	1.78 ml	3.561 ml
10 mM	0.178 ml	0.89 ml	1.78 ml
50 mM	0.036 ml	0.178 ml	0.356 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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AT406 (SM-406)