貨號	規(guī)格	價格	上海	北京	武漢	南京
S81195-5mg	98.7%	￥230.00 S81195-5mg ￥230.00 現(xiàn)貨	6 6	-	-	-
S81195-10mg	98.7%	￥390.00 S81195-10mg ￥390.00 現(xiàn)貨	6 6	-	-	-
S81195-25mg	98.7%	￥770.00 S81195-25mg ￥770.00 現(xiàn)貨	6 6	-	-	-
S81195-50mg	98.7%	￥1400.00 S81195-50mg ￥1400.00 現(xiàn)貨	5 5	-	-	-
S81195-100mg	≥98%	￥2200.00 S81195-100mg ￥2200.00 2-3天	0 貨期：2-3天	-	-	-
S81195-200mg	≥98%	￥2900.00 S81195-200mg ￥2900.00 2-3天	0 貨期：2-3天	-	-	-

大包裝詢價收藏產(chǎn)品

加入購物車

產(chǎn)品介紹

SBE13 Hydrochloride is a potent and selective Plk1 inhibitor, with an IC50 of 200 pM; SBE13 Hydrochloride poorly inhibits Plk2 (IC50>66?μM) or Plk3 (IC50=875?nM).

產(chǎn)品描述：

SBE13 Hydrochloride is a potent and selective Plk1 inhibitor, with an IC50 of 200 pM; SBE13 Hydrochloride poorly inhibits Plk2 (IC50>66?μM) or Plk3 (IC50=875?nM).

靶點：

PLK1:200 pM (IC50);PLK3:875 nM (IC50);Apoptosis;?PLK;?Autophagy

體外研究：

SBE13 significantly reduce cell proliferation and induce apoptosis in HeLa cells, with an EC50 of 18?μM. SBE13 (1-100 μM) shows no effect on Caspase 3/7 activity in NIH-3T3 cells. SBE13 (66 and 100 μM) does not change morphology after treatment of primary cells. SBE13 (10 and 100 μM) reduces pRb staining in primary cells, and this indicates a G0/G1 arrest. SBE13 (66 and 100 μM) increases levels of cyclin B1, phospho histone H3, Wee1, Emi1 and securin, and results in cleavage of Cdc27 in HeLa cells. SBE13 (10 and 100 μM) also induces apoptosis of HeLa cells

參考文獻(xiàn)：

1. Keppner S, et al. Identification and validation of a potent type II inhibitor of inactive polo-like kinase 1. ChemMedChem. 2009 Nov;4(11):1806-9. 2. Keppner S, et al. Fate of primary cells at the G?/S boundary after polo-like kinase 1 inhibition by SBE13. Cell Cycle. 2011 Feb 15;10(4):708-20. Epub 2011 Feb 15. 3. Keppner S, et al. Biological impact of freezing Plk1 in its inactive conformation in cancer cells. Cell Cycle. 2010 Feb 15;9(4):761-73. Epub 2010 Feb 16.

溶解性：

Soluble in DMSO、H2O

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.086 ml	10.43 ml	20.86 ml
5 mM	0.417 ml	2.086 ml	4.172 ml
10 mM	0.209 ml	1.043 ml	2.086 ml
50 mM	0.042 ml	0.209 ml	0.417 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

質(zhì)檢證書(COA)

輸入產(chǎn)品批號：

如何獲取質(zhì)檢證書(COA)?

請輸入貨號和一個與之匹配的批號。
例如:
批號：JS298415 貨號：S20001-25g
在貨品標(biāo)簽上如何找到貨號和批號?

摩爾濃度計算器

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

質(zhì)量

濃度

體積

分子摩爾量

計算重置

玖玖资源网站,爆乳久久久,日韩精品乱码久久久蜜桃,精品呦国产一区二区三区,国产伦高清一区二区三区,sese一区二区,午夜精品福利一区二区三区,三级黄色网站久久免费

SBE13 (Hydrochloride)