貨號	規格	價格	上海	北京	武漢	南京
S81172-5mg	99.9%	￥350.00 S81172-5mg ￥350.00 現貨	3609 >10	-	-	-
S81172-10mg	99.9%	￥500.00 S81172-10mg ￥500.00 現貨	1810 >10	-	-	-
S81172-50mg	99.9%	￥1290.00 S81172-50mg ￥1290.00 現貨	367 >10	-	-	-
S81172-250mg	99.9%	￥3200.00 S81172-250mg ￥3200.00 現貨	78 >10	-	-	-

產品介紹

Dapagliflozin propanediol belongs to the class of orally administered antidiabetic agents designated as sodiumglucose cotransporter 2 (SGLT2) inhibitors

產品描述：

Dapagliflozin propanediol belongs to the class of orally administered antidiabetic agents designated as sodiumglucose cotransporter 2 (SGLT2) inhibitors

靶點：

SGLT2;SGLT

體外研究：

Dapagliflozin is a small-molecule inhibitor of SGLT2 that has been shown to be highly selective for SGLT2 compared with other SGLT family members and to have no off-target interactions in an in vitro screen of more than 330 receptors, enzymes, ion channels, and transporters

體內研究：

Dapagliflozin demonstrates good oral bioavailability, has a high volume of distribution, and has an in vivo metabolite profile that is qualitatively similar between preclinical species and humans. Both non-clinical and clinical assessments have shown dapagliflozin to have a highly favorable safety profile that is consistent with its simple mechanism of action, with no off-target effects observed

動物實驗：

Animal Models: Sprague-Dawley (SD) rats Dosages: 25, 100, 150, or 200 mg/kg Administration: oral

參考文獻：

1. Reilly TP, et al. Carcinogenicity risk assessment supports the chronic safety of dapagliflozin, an inhibitor of sodium-glucose co-transporter 2, in the treatment of type 2 diabetes mellitus. Diabetes Ther. 2014, 5(1):73-96.

溶解性：

Soluble in DMSO、Ethanol

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.988 ml	9.941 ml	19.881 ml
5 mM	0.398 ml	1.988 ml	3.976 ml
10 mM	0.199 ml	0.994 ml	1.988 ml
50 mM	0.04 ml	0.199 ml	0.398 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

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Dapagliflozin ((2S)-1,2-propanediol, hydrate)