貨號	規格	價格	上海	北京	武漢	南京
S81160-5mg	98.0%	￥245.00 S81160-5mg ￥245.00 現貨	7 7	-	-	-
S81160-10mg	98.0%	￥390.00 S81160-10mg ￥390.00 現貨	9 9	-	-	-
S81160-50mg	98.0%	￥1130.00 S81160-50mg ￥1130.00 現貨	7 7	-	-	-
S81160-100mg	98.0%	￥1850.00 S81160-100mg ￥1850.00 現貨	3 3	-	-	-

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產品介紹

Adavosertib (AZD-1775; MK-1775) is a potent Wee1 inhibitor with an IC50 of 5.2 nM.

產品描述：

Adavosertib (AZD-1775; MK-1775) is a potent Wee1 inhibitor with an IC50 of 5.2 nM.

靶點：

IC50: 5.2 nM (Wee1);Wee1

體內研究：

In vivo, Adavosertib (MK-1775) potentiates the anti-tumor efficacy of 5-FU at tolerable doses[1]. Adavosertib (MK-1775) (60 mg/kg twice daily, p.o.) enhances H1299 xenograft tumor response to fractionated radiotherapy. Adavosertib (MK-1775) (30 mg/kg. p.o.) regresses tumor growth in PANC198, PANC215 and PANC185 as compared to GEM treated mice

參考文獻：

1. Hirai H, et al. MK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-FU. Cancer Biol Ther. 2010 Apr;9(7):514-22. 2. Bridges KA, et al. MK-1775, a novel Wee1 kinase inhibitor, radiosensitizes p53-defective human tumor cells. Clin Cancer Res. 2011 Sep 1;17(17):5638-48. Epub 2011 Jul 28. 3. Rajeshkumar NV, et al. MK-1775, a potent Wee1 inhibitor, synergizes with NSC 613327 to achieve tumor regressions, selectively in p53-deficient pancreatic cancer xenografts.Clin Cancer Res. 2011 May 1;17(9):2799-806. Epub 2011 Mar 9.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.998 ml	9.988 ml	19.976 ml
5 mM	0.4 ml	1.998 ml	3.995 ml
10 mM	0.2 ml	0.999 ml	1.998 ml
50 mM	0.04 ml	0.2 ml	0.4 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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Adavosertib (AZD1775; MK-1775)

2-allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1,2-dihydropyrazolo[3,4-d]pyrimidin-3-one