貨號	規格	價格	上海	北京	武漢	南京
S81147-5mg	≥99%	￥720.00 S81147-5mg ￥720.00 現貨	10 10	-	-	-
S81147-10mg	≥99%	￥1150.00 S81147-10mg ￥1150.00 現貨	10 10	-	-	-
S81147-50mg	≥99%	￥5046.00 S81147-50mg ￥5046.00 現貨	8 8	-	-	-
S81147-100mg	≥99%	￥7200.00 S81147-100mg ￥7200.00 現貨	4 4	-	-	-

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產品介紹

CCT129202 is an aurora kinase inhibitor with IC50s of 42, 198, and 227 nM for aurora A, B and C, respectively.

產品描述：

CCT129202 is an aurora kinase inhibitor with IC50s of 42, 198, and 227 nM for aurora A, B and C, respectively.

靶點：

Aurora A:42 nM (IC50);Aurora B:198 nM (IC50);Aurora C:227 nM (IC50);AuroraKinase

體內研究：

Growth of HCT116 xenografts in nude mice is inhibited after i.p. administration of CCT129202. p21, the cyclin-dependent kinase inhibitor, is induced by CCT129202. Up-regulation of p21 by CCT129202 in HCT116 cells led to Rb hypophosphorylation and E2F inhibition, contributing to a decrease in thymidine kinase 1 transcription

參考文獻：

1. Chan F, et al. Mechanism of action of the Aurora kinase inhibitor CCT129202 and in vivo quantification of biological activity. Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3147-57.

溶解性：

Soluble in DMSO

保存條件：

-20°C

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.012 ml	10.06 ml	20.12 ml
5 mM	0.402 ml	2.012 ml	4.024 ml
10 mM	0.201 ml	1.006 ml	2.012 ml
50 mM	0.04 ml	0.201 ml	0.402 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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CCT129202

2-(4-(6-chloro-2-(4-(dimethylamino)phenyl)-3H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)-N-(thiazol-2-yl)acetamide